SynthesisBioscience reports2018
The role of perineural invasion in penile cancer: a meta-analysis and systematic review.
Synthesis in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Prognostic predictors of lymph node metastasis in penile cancer: a systematic review.International braz j urol : official journal of the Brazilian Society of UrologyPooled it
- Outcomes of Adjuvant Radiation Therapy in Penile Cancer.Advances in radiation oncology · 2026Article
- New histological risk grading system for prediction of lymph node metastasis in patients with penile cancer.Virchows Archiv : an international journal of pathology · 2025Article
- Factors predictive of recurrence, metastasis and death in node-negative penile squamous cell carcinoma: A retrospective multicentre cohort study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- MIR-376A-2-5P as a potential prognostic marker for advanced penile squamous cell carcinomas trough HPV-dependent pathways.American journal of cancer research · 2023Article
- What would one of the greatest natural scientists and educators of the eighteenth century, Georg Christoph Lichtenberg, say about the current therapy management of patients with penile cancer?Journal of cancer research and clinical oncology · 2022Article
- Non-Coding RNA in Penile Cancer.Frontiers in oncology · 2022Review
- Downregulation of miR-145 is associated with perineural invasion in penile carcinoma.Translational andrology and urology · 2021Article
- What you need to know: updates in penile cancer staging.World journal of urology · 2021Review
- Microscopic Invasion of Nerve Is Associated With Aggressive Behaviors in Pancreatic Neuroendocrine Tumors.Frontiers in oncology · 2021Article
- Nomograms to predict overall and cancer-specific survival in patients with penile cancer.Translational cancer research · 2020Article
- Novel Prognostic Models for Patients With Penile Carcinoma.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The significance of perineural invasion (PNI) present in penile cancer (PC) is controversial. In order to clarify the predictive role of PNI in the inguinal lymph node (ILN) metastases (ILNM) and oncologic outcome of patients, we performed this meta-analysis and systematic review. The search of PubMed, Embase, and Web of Science was conducted for appropriate studies, up to 20 January 2018. The pooled odds ratio (OR) and hazard ratio (HR) with their 95% confidence interval (CI) were applied to evaluate the difference in ILNM and oncologic outcome between patients present with PNI and those who were absent. A total of 298 in 1001 patients present with PNI were identified in current meta-analysis and systematic review. Significant difference was observed in ILNM between PNI present and absent from patients with PC (OR = 2.98, 95% CI = 2.00-4.45). Patients present with PNI had a worse cancer-specific survival (CSS) (HR = 3.58, 95% CI = 1.70-7.55) and a higher cancer-specific mortality (CSM) (HR = 2.20, 95% CI = 1.06-3.82) than those cases without PNI. This meta-analysis and systematic review demonstrated the predictive role of PNI in ILNM, CSS, and CSM for PC patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.