ArticleCancer discovery2019
Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility.
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Article in Cancer discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 283 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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283citing papers in PubMed, 2 pooled it
31.8field-weighted citation impact, top 1% of its field
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Who cites it
283 citing papers in PubMed, 2 syntheses or guidelines pooled it, 406 citations in OpenAlex.
- Cellular Senescence and Immunosenescence in Melanoma: Insights From the Tumor Microenvironment.Cancer medicine · 2025Pooled it
- Analysis of mutations in cutaneous squamous cell carcinoma reveals novel genes and mutations associated with patient-specific characteristics and metastasis: a systematic review.Archives of dermatological research · 2022Pooled it
- Immune dysregulation in the prostates of C57BL/6The Journal of pathology · 2026Article
- Review
- Mechanical cues of an interpenetrating polysaccharide matrix regulate self-assembly of collagen fibers.Science advances · 2026Article
- Enhanced Transdermal Delivery of rhHAPLN1 by SoluballPharmaceutics · 2026Article
- Review
- Illuminating aging with multimodal optical metabolic imaging.Science advances · 2026Review
- Single-cell multi-omics dissection of RevitalAge Markers uncovers age-dependent immunotherapy resistance and druggable targets in melanoma.Biology direct · 2026Article
- Extracellular matrix stiffness determines the phenotypic behavior of dedifferentiated melanoma cells through a DDR1/2-dependent YAP mechanotransduction pathway.Oncogenesis · 2026Article
- The exosomal miRNA/FOXN3 axis empowers fibroblasts with tumor-promoting functions via enhanced migration and altered secretome.Journal of nanobiotechnology · 2026Article
- Mechanobiology of solid tumor vasculature: implications for tumor progression.Cancer metastasis reviews · 2026Review
- Spatial transcriptomics reveals influence of microenvironment on intrinsic fates in melanoma therapy resistance.Genome biology · 2026Article
- Aging promotes a RAGE-dependent increase in breast cancer metastasis.Communications biology · 2026Article
- Cancer-associated fibroblasts -derived Tenascin-C activates the Hippo/TAZ pathway to suppress ferroptosis and confer cisplatin resistance in esophageal cancer.Scientific reports · 2026Article
- Article
- The extracellular matrix: structure, composition, biological functions, diseases, and therapeutic targets.Molecular biomedicine · 2026Review
- The extracellular matrix in inflammation and cancer.Molecular biomedicine · 2026Review
- Of Barriers and Loops-How Evolution Limits Most Cancer Risks to Older Ages.Cancer discovery · 2026Review
- Remodeling the tumor dormancy ecosystem to prevent recurrence and metastasis.Signal transduction and targeted therapy · 2026Review
223 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 4 institutions in 1 country.
Amanpreet KaurDepartment of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania.ORCID 0000-0002-4228-2742
Brett L EckerThe Wistar Institute, Philadelphia, Pennsylvania.
Stephen M DouglassThe Wistar Institute, Philadelphia, Pennsylvania.
Curtis H KugelThe Wistar Institute, Philadelphia, Pennsylvania.
Marie R WebsterThe Wistar Institute, Philadelphia, Pennsylvania.
Filipe V AlmeidaThe Wistar Institute, Philadelphia, Pennsylvania.
Rajasekharan SomasundaramThe Wistar Institute, Philadelphia, Pennsylvania.
James HaydenThe Wistar Institute, Philadelphia, Pennsylvania.
Ehsan BanSchool of Engineering and Applied Science, Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Hossein AhmadzadehSchool of Engineering and Applied Science, Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Janusz Franco-BarrazaCancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.ORCID 0000-0003-3652-5311
Neelima ShahCancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Ian A MellisSchool of Engineering and Applied Science, Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-6239-4821
Frederick KeeneyThe Wistar Institute, Philadelphia, Pennsylvania.
Andrew KossenkovThe Wistar Institute, Philadelphia, Pennsylvania.
Hsin-Yao TangThe Wistar Institute, Philadelphia, Pennsylvania.ORCID 0000-0003-1838-018X
Xiangfan YinThe Wistar Institute, Philadelphia, Pennsylvania.
Qin LiuThe Wistar Institute, Philadelphia, Pennsylvania.ORCID 0000-0001-9964-580X
Xiaowei XuDepartment of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania.
Mitchell FaneThe Wistar Institute, Philadelphia, Pennsylvania.ORCID 0000-0001-6163-5753
Patricia BraffordThe Wistar Institute, Philadelphia, Pennsylvania.
Meenhard HerlynThe Wistar Institute, Philadelphia, Pennsylvania.
David W SpeicherThe Wistar Institute, Philadelphia, Pennsylvania.
Jennifer A WargoThe University of Texas MD Anderson Cancer Center, Houston, Texas.
Michael T TetzlaffThe University of Texas MD Anderson Cancer Center, Houston, Texas.
Lauren E HayduThe University of Texas MD Anderson Cancer Center, Houston, Texas.
Arjun RajSchool of Engineering and Applied Science, Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-2915-6960
Vivek ShenoySchool of Engineering and Applied Science, Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Edna CukiermanCancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.ORCID 0000-0002-1452-9576
Ashani T WeeraratnaThe Wistar Institute, Philadelphia, Pennsylvania. aweeraratna@wistar.org.
The Wistar Institute · USUniversity of Pennsylvania · USFox Chase Cancer Center · USThe University of Texas MD Anderson Cancer Center · US
Funding
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MTargeting the MAP and PI3 Kinase Pathways in MelanomaP01CA114046 · NCI · WISTAR INSTITUTE · PI HERLYN, MEENHARD F, WEERARATNA, ASHANI T · 2008 to 2023
$37.1MTRAINING PROGRAM IN BASIC CANCER RESEARCHT32CA009171 · NCI · WISTAR INSTITUTE · PI Alessandro Gardini · 1985 to 2026
$15.3MTargeted Combination Therapy for MelanomaP50CA174523 · NCI · WISTAR INSTITUTE · PI HERLYN, MEENHARD F · 2014 to 2018
$11.1MIdentification of Ovarian Cancer Plasma BiomarkersR01CA131582 · NCI · WISTAR INSTITUTE · PI SPEICHER, DAVID W. · 2009 to 2018
$4.1MA plasticity and reprogramming paradigm for therapy resistance at the single cell levelU01CA227550 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RADHAKRISHNAN, RAVI, RAJ, ARJUN · 2018 to 2022
$3.3M3D-Adhesion Stromagenesis in Cancer PermissivenessR01CA113451 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI CUKIERMAN, EDNA · 2006 to 2016
$2.8MAdvancing Cancer Research through Comprehensive Proteomics and Metabolomics AnalysesR50CA221838 · NCI · WISTAR INSTITUTE · PI Hsin-Yao Tang · 2017 to 2026
$2.1MPromotion of tumor invasion and pseudosenescence by the aging microenvironmentR01CA174746 · NCI · WISTAR INSTITUTE · PI WEERARATNA, ASHANI T · 2014 to 2018
$2.1MEffect of the aged microenvironment on tumor dormancyR01CA207935 · NCI · WISTAR INSTITUTE · PI WEERARATNA, ASHANI T · 2017 to 2021
$2.0MIntegrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6MNCI NIH HHS F99 CA212437NCI NIH HHS K00 CA212437NCI NIH HHS K99 CA208012NCI NIH HHS P01 CA114046NCI NIH HHS P30 CA006927NCI NIH HHS P30 CA010815NCI NIH HHS P50 CA174523NCI NIH HHS R01 CA113451NCI NIH HHS R01 CA131582NCI NIH HHS R01 CA174746NCI NIH HHS R01 CA207935NCI NIH HHS R50 CA211199NCI NIH HHS R50 CA221838NCI NIH HHS T32 CA009171NCI NIH HHS U01 CA227550
Abstract
Physical changes in skin are among the most visible signs of aging. We found that young dermal fibroblasts secrete high levels of extracellular matrix (ECM) constituents, including proteoglycans, glycoproteins, and cartilage-linking proteins. The most abundantly secreted was HAPLN1, a hyaluronic and proteoglycan link protein. HAPLN1 was lost in aged fibroblasts, resulting in a more aligned ECM that promoted metastasis of melanoma cells. Reconstituting HAPLN1 inhibited metastasis in an aged microenvironment, in 3-D skin reconstruction models, and
Indexed as
AgingAnimalsCells, CulturedCollagenExtracellular Matrix ProteinsFibroblastsHumansImmune SystemMelanomaMiceMice, Inbred C57BLNeoplasm MetastasisProteoglycan Link ProteinProteoglycansSkinTumor MicroenvironmentCollagenExtracellular Matrix ProteinsProteoglycan Link ProteinProteoglycans
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.