Evidence map›Paper›PMID 30278820›Full record

SynthesisRenal failure2018

Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis.

Jiaxuan Qin, Jinchun Xing, Wei Li, Kaiyan Zhang, Zhun Wu

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Renal failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiaxuan Qina Department of Urology Surgery , The First Affiliated Hospital of Xiamen University , Xiamen , Fujian , China.
Jinchun Xinga Department of Urology Surgery , The First Affiliated Hospital of Xiamen University , Xiamen , Fujian , China.
Wei Lia Department of Urology Surgery , The First Affiliated Hospital of Xiamen University , Xiamen , Fujian , China.
Kaiyan Zhanga Department of Urology Surgery , The First Affiliated Hospital of Xiamen University , Xiamen , Fujian , China.
Zhun Wua Department of Urology Surgery , The First Affiliated Hospital of Xiamen University , Xiamen , Fujian , China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivePrevious studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main results: Two investigators search databases systematically and independently. Odds ratios and 95% confidence intervals were used to pool the effect size. Four articles with 618 cases and 932 controls in total were included in our meta-analysis.

conclusionsMPO -463G > A was not associated with CKD susceptibility in recessive model and homozygote comparison. MPO -463G > A was associated with increased risk of CKD in allelic comparison, heterozygote comparison and dominant model, however, the results lacked stability. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed.

Indexed as

Polymorphism, Single NucleotideAllelesCase-Control StudiesGenetic Predisposition to DiseaseHumansLogistic ModelsPeroxidaseRenal Insufficiency, ChronicRisk FactorsMPO protein, humanPeroxidasechronic kidney diseasemeta-analysisMyeloperoxidasers2333227single nucleotide polymorphism

Identifiers

PMID30278820
PMCPMC6171445

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.