Evidence map›Paper›PMID 30278816›Full record

ArticleJournal of biological rhythms2019

A Novel Diabetic Mouse Model for Real-Time Monitoring of Clock Gene Oscillation and Blood Pressure Circadian Rhythm.

Tianfei Hou, Wen Su, Zhenheng Guo, Ming C Gong

Open access · greenAbstract read
In one paragraph

Article in Journal of biological rhythms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
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  5. Diabetes Reshapes the Circadian Transcriptome Profile in Murine Retina.Investigative ophthalmology & visual science · 2023
    Article
  6. Review
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  9. Article
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  11. Review
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  14. Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  15. Review
  16. Review
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  18. Old and New Roles and Evolving Complexities of Cardiovascular Clocks.The Yale journal of biology and medicine · 2019
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tianfei HouDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky.
Wen SuDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky.
Zhenheng GuoDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky.
Ming C GongDepartment of Physiology, University of Kentucky, Lexington, Kentucky.
University of Kentucky · USLexington VA Health Care System · US

Funding

The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2012 to 2017
$13.7M
Targeting timing of food intake as a novel strategy against disruption of blood pressure circadian rhythm in diabetesR01HL141103 · NHLBI · UNIVERSITY OF KENTUCKY · PI GONG, MING C, GUO, ZHENHENG · 2019 to 2022
$2.5M
Mineralocorticoid receptor and abdominal aortic aneurysmR01HL125228 · NHLBI · UNIVERSITY OF KENTUCKY · PI GONG, MING C, GUO, ZHENHENG · 2015 to 2018
$2.1M
Regulation of Blood Pressure Circadian Rhythm by Vascular Smooth Muscle BMAL1R01HL106843 · NHLBI · UNIVERSITY OF KENTUCKY · PI GONG, MING C, GUO, ZHENHENG · 2012 to 2015
$2.0M
NHLBI NIH HHS R01 HL106843NHLBI NIH HHS R01 HL125228NHLBI NIH HHS R01 HL141103NIGMS NIH HHS P20 GM103527
6 · The paper itself

Abstract

Diabetic patients have an increased prevalence of blood pressure (BP) circadian rhythm disruption, which is associated with an increased risk of target organ damage and detrimental cardiovascular events. Limited information is available regarding the role of clock genes in the disruption of BP circadian rhythm in diabetes due to the lack of a diabetic animal model that allows real-time monitoring of clock gene oscillation. Here, we generated a novel diabetic db/db-mPer2

Indexed as

Blood PressureCircadian RhythmDisease Models, AnimalAnimalsCircadian ClocksDiabetes Mellitus, ExperimentalFemaleMaleMiceMice, Inbred C57BLPeriod Circadian ProteinsSuprachiasmatic NucleusPer2 protein, mousePeriod Circadian Proteinsbaroreflex sensitivityblood pressurecircadian rhythmclock genediabeteslocomotor activitymetabolismmicePer2

Identifiers

PMID30278816
PMCPMC6757342
OpenAlexW2895746148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.