Evidence map›Paper›PMID 30278796›Full record

ArticleRenal failure2018

Serum NGAL and FGF23 may have certain value in early diagnosis of CIN.

Huihui Li, Zaixin Yu, Lu Gan, Ling Peng, Qiaoling Zhou

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In one paragraph

Article in Renal failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Huihui Lia Department of Nephropathy , Xiangya Hospital Central-South University , Changsha , Hunan 410008 , China.
Zaixin Yub Department of Cardiology , Xiangya Hospital Central-South University , Changsha , Hunan 410008 , China.
Lu Gana Department of Nephropathy , Xiangya Hospital Central-South University , Changsha , Hunan 410008 , China.
Ling Penga Department of Nephropathy , Xiangya Hospital Central-South University , Changsha , Hunan 410008 , China.
Qiaoling Zhoua Department of Nephropathy , Xiangya Hospital Central-South University , Changsha , Hunan 410008 , China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis study aimed to assess whether neutrophil gelatinase-associated lipocalin (NGAL) and fibroblast growth factor 23 (FGF23) could be reliable biomarkers for early diagnosis of contrast-induced nephropathy (CIN).

methods202 patients who underwent percutaneous coronary intervention (PCI) were included in the research. All subjects were divided into CIN group and non-CIN group. Serum NGAL and FGF23 were evaluated before and 0, 1, and 2 days after PCI. Serum levels of these two markers were compared intra-group and among groups. Receiver-operating characteristic (ROC) analysis and logistic regression models were conducted to assess the diagnostic performance of NGAL and FGF23 in detecting CIN.

resultsWhen compared with baseline values, serum levels of both NGAL and FGF23 in all subjects increased after PCI, and the values peaked 1 day after PCI, but the changing was greater in CIN group. There were obvious differences between two groups in serum NGAL after 1, 2 days, and similar differences present in serum FGF23 after 1 day. ROC analysis showed that the area under the curve (AUC) of relative values (percent change from the baseline) in NGAL after 1 day was 0.899 (95% CI: 0.834-0.964, p = .000), the optimum cutoff was 49% (sensitivity = 80%, specificity = 92.4%). And the AUC in FGF23 was 0.814 (95% CI: 0.733-0.894, p = .000), the optimum cutoff was 20% (sensitivity = 73.3%, specificity = 87.6%). Both serum NGAL and serum FGF23 could improve the clinical models in identifying CIN.

conclusionsNGAL and FGF23 may have certain value in early diagnosis of CIN.

Indexed as

Early DiagnosisAcute Kidney InjuryAgedBiomarkersChinaContrast MediaCoronary AngiographyFemaleFibroblast Growth Factor 2Fibroblast Growth Factor-23HumansLipocalin-2Logistic ModelsMaleMiddle AgedPercutaneous Coronary InterventionBiomarkersContrast MediaFGF23 protein, humanFibroblast Growth Factor 2Fibroblast Growth Factor-23Lipocalin-2contrast-induced nephropathyfibroblast growth factor 23Neutrophil gelatinase-associated lipocalinpercutaneous coronary intervention

Identifiers

PMID30278796
PMCPMC6171456

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.