Evidence map›Paper›PMID 30278791›Full record

ArticleThe American journal of psychiatry2018

Impaired Motion Processing in Schizophrenia and the Attenuated Psychosis Syndrome: Etiological and Clinical Implications.

Antígona Martínez, Pablo A Gaspar, Steven A Hillyard, Søren K Andersen, Javier Lopez-Calderon, Cheryl M Corcoran, Daniel C Javitt

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Antígona MartínezFrom the Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y.; the Department of Psychiatry, Columbia University Medical Center, New York; the Department of Psychiatry, School of Medicine, University of Chile, Santiago; the Department of Neurosciences, University of California, San Diego, La Jolla; the School of Psychology, University of Aberdeen, Aberdeen, United Kingdom; the Facultad de Ingeniería, Universidad Autónoma de Chile, Talca; and the Icahn School of Medicine at Mount Sinai, New York.
Pablo A GasparFrom the Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y.; the Department of Psychiatry, Columbia University Medical Center, New York; the Department of Psychiatry, School of Medicine, University of Chile, Santiago; the Department of Neurosciences, University of California, San Diego, La Jolla; the School of Psychology, University of Aberdeen, Aberdeen, United Kingdom; the Facultad de Ingeniería, Universidad Autónoma de Chile, Talca; and the Icahn School of Medicine at Mount Sinai, New York.
Steven A HillyardFrom the Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y.; the Department of Psychiatry, Columbia University Medical Center, New York; the Department of Psychiatry, School of Medicine, University of Chile, Santiago; the Department of Neurosciences, University of California, San Diego, La Jolla; the School of Psychology, University of Aberdeen, Aberdeen, United Kingdom; the Facultad de Ingeniería, Universidad Autónoma de Chile, Talca; and the Icahn School of Medicine at Mount Sinai, New York.
Søren K AndersenFrom the Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y.; the Department of Psychiatry, Columbia University Medical Center, New York; the Department of Psychiatry, School of Medicine, University of Chile, Santiago; the Department of Neurosciences, University of California, San Diego, La Jolla; the School of Psychology, University of Aberdeen, Aberdeen, United Kingdom; the Facultad de Ingeniería, Universidad Autónoma de Chile, Talca; and the Icahn School of Medicine at Mount Sinai, New York.
Javier Lopez-CalderonFrom the Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y.; the Department of Psychiatry, Columbia University Medical Center, New York; the Department of Psychiatry, School of Medicine, University of Chile, Santiago; the Department of Neurosciences, University of California, San Diego, La Jolla; the School of Psychology, University of Aberdeen, Aberdeen, United Kingdom; the Facultad de Ingeniería, Universidad Autónoma de Chile, Talca; and the Icahn School of Medicine at Mount Sinai, New York.
Cheryl M CorcoranFrom the Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y.; the Department of Psychiatry, Columbia University Medical Center, New York; the Department of Psychiatry, School of Medicine, University of Chile, Santiago; the Department of Neurosciences, University of California, San Diego, La Jolla; the School of Psychology, University of Aberdeen, Aberdeen, United Kingdom; the Facultad de Ingeniería, Universidad Autónoma de Chile, Talca; and the Icahn School of Medicine at Mount Sinai, New York.
Daniel C JavittFrom the Nathan Kline Institute for Psychiatric Research, Orangeburg, N.Y.; the Department of Psychiatry, Columbia University Medical Center, New York; the Department of Psychiatry, School of Medicine, University of Chile, Santiago; the Department of Neurosciences, University of California, San Diego, La Jolla; the School of Psychology, University of Aberdeen, Aberdeen, United Kingdom; the Facultad de Ingeniería, Universidad Autónoma de Chile, Talca; and the Icahn School of Medicine at Mount Sinai, New York.
Nathan Kline Institute for Psychiatric Research · US

Funding

EARLY CORTICAL PROCESSING IN SCHIZOPHRENIAR01MH049334 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI JAVITT, DANIEL C. · 1998 to 2022
$8.8M
Thought disorder and social cognition in clinical risk states for schizophreniaR01MH107558 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI CORCORAN, CHERYL MARY · 2016 to 2020
$3.3M
PHENCYCLIDINE ABUSE &PSYCHOSIS--BIOMEDICAL MECHANISMSR01DA003383 · NIDA · YESHIVA UNIVERSITY · PI JAVITT, DANIEL C. · 1985 to 2010
$3.2M
Using the RDoC Approach to Understand Thought Disorder: A Linguistic Corpus-Based ApproachR01MH115332 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CORCORAN, CHERYL MARY · 2018 to 2020
$1.6M
Functional connectivity and DTI in schizophreniaR21MH084031 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI HOPTMAN, MATTHEW J · 2009 to 2010
$428k
NIDA NIH HHS R01 DA003383NIMH NIH HHS R01 MH049334NIMH NIH HHS R01 MH107558NIMH NIH HHS R01 MH115332NIMH NIH HHS R21 MH084031
6 · The paper itself

Abstract

objectiveThe ability to perceive the motion of biological objects, such as faces, is a critical component of daily function and correlates with the ability to successfully navigate social situations (social cognition). Deficits in motion perception in schizophrenia were first demonstrated about 20 years ago but remain understudied, especially in the early, potentially prodromal, stages of the illness. The authors examined the neural bases of visual sensory processing impairments, including motion, in patients with schizophrenia (N=63) and attenuated psychosis (clinical high risk) (N=32) compared with age-matched healthy control subjects (N=67).

methodElectrophysiological recordings during stimulus and motion processing were analyzed using oscillatory (time frequency) approaches that differentiated motion-onset-evoked activity from stimulus-onset sensory-evoked responses. These were compared with functional MRI (fMRI) measures of motion processing.

resultsSignificant deficits in motion processing were observed across the two patient groups, and these deficits predicted impairments in both face-emotion recognition and cognitive function. In contrast to motion processing, sensory-evoked stimulus-onset responses were intact in patients with attenuated psychosis, and, further, the relative deficit in motion-onset responses compared with stimulus-onset responses predicted transition to schizophrenia. In patients with schizophrenia, motion detection deficits mapped to impaired activation in motion-sensitive visual cortex during fMRI. Additional visual impairments in patients with schizophrenia, not present in patients with attenuated psychosis, implicated other visual regions, including the middle occipital gyrus and pulvinar thalamic nucleus.

conclusionsThe study findings emphasize the importance of sensory-level visual dysfunction in the etiology of schizophrenia and in the personal experience of individuals with the disorder and demonstrate that motion-processing deficits may predate illness onset and contribute to impaired function even in patients with attenuated psychosis.

Indexed as

Motion PerceptionAdultBrainCase-Control StudiesElectroencephalographyEvoked Potentials, VisualFemaleHumansMagnetic Resonance ImagingMaleNeuroimagingNeuropsychological TestsProdromal SymptomsPsychiatric Status Rating ScalesSchizophreniaSyndromeElectroencephalographyNeurophysiologyProdromeSchizophreniaVisual Processing

Identifiers

PMID30278791
PMCPMC6408222
OpenAlexW2887136599

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.