ArticleSeminars in thoracic and cardiovascular surgery2019
Pulmonary Vein Stenosis: Outcomes in Children With Congenital Heart Disease and Prematurity.
Article in Seminars in thoracic and cardiovascular surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Interventional Strategies for Children with Progressive Pulmonary Hypertension Despite Optimal Therapy: An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2025Guideline
- Catheter and echocardiographic-focused management of primary pulmonary vein stenosis in premature infants: a single center 5-year experience.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Feasibility of Electric Impedance Tomography in the Assessment of Lung Perfusion and Ventilation in Congenital Pulmonary Vein Stenosis.Pediatric cardiology · 2026Article
- Pulmonary vein stenosis after pediatric heart transplantation: incidence and risk factors.Frontiers in surgery · 2026Article
- Serial echocardiography in preterm infants with bronchopulmonary dysplasia: diagnosing and managing recurrent pulmonary vein stenosis.Case reports in perinatal medicine · 2025Article
- Outcomes and Risk Factors of Interventions for Pediatric Post-operative Pulmonary Vein Stenosis.Pediatric cardiology · 2023Article
- The Complementary Value of Proximal Isovelocity Surface Area in Large Left-to-Right Lesions With Pulmonary Vein Stenosis.CASE (Philadelphia, Pa.) · 2023Article
- Predictors of Serious Adverse Events and High-Level Cardiorespiratory Support in Patients Undergoing Transcatheter Pulmonary Vein Interventions.Pediatric cardiology · 2023Article
- Prematurity and Pulmonary Vein Stenosis: The Role of Parenchymal Lung Disease and Pulmonary Vascular Disease.Children (Basel, Switzerland) · 2022Review
- Lung and Pleural Findings of Children with Pulmonary Vein Stenosis with and without Aspiration: MDCT Evaluation.Children (Basel, Switzerland) · 2022Article
- Secondary Pulmonary Vein Stenosis Due to Total Anomalous Pulmonary Venous Connection Repair in Children: Extravascular MDCT Findings.Children (Basel, Switzerland) · 2021Article
- Pulmonary Vein Stenosis in Children: A Programmatic Approach Employing Primary and Anatomic Therapy.Children (Basel, Switzerland) · 2021Article
- Primary pulmonary vein stenosis during infancy: state of the art review.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Pulmonary Vein Stenosis: Incremental Knowledge Gains to Improve Outcomes.Children (Basel, Switzerland) · 2021Article
- Outcomes in Establishing Individual Vessel Patency for Pediatric Pulmonary Vein Stenosis.Children (Basel, Switzerland) · 2021Article
- Pulmonary Vein Stenosis: A Rare Disease with a Global Reach.Children (Basel, Switzerland) · 2021Article
- Treatment of Congenital and Acquired Pulmonary Vein Stenosis.Current cardiology reports · 2020Review
- Border Medicine: The Pediatric Cardiology Perspective.Pediatric cardiology · 2020Article
- Management of Pediatric Pulmonary Vein Stenosis.Journal of the Society for Cardiovascular Angiography & InterventionsReview
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7 authors at 3 institutions in 1 country.
Funding
Abstract
Pulmonary vein stenosis (PVS) is a rare condition that has been linked to prematurity and congenital heart disease (CHD). Despite these associations, treatment options are limited and outcomes are guarded. We investigated differences in PVS outcomes based on the presence of CHD and prematurity, and risk factors for mortality or lung transplantation in PVS. Single-center retrospective cohort study of patients diagnosed with PVS between January 2005 and May 2016 and identified by ICD codes with chart validation. Cox proportional hazard models assessed risk factors for the composite outcome of mortality or lung transplantation. Ninety-three patients with PVS were identified: 65 (70%) had significant CHD, 32 (34%) were premature, and 14 (15%) were premature with CHD. Sixty-five (70%) underwent a PVS intervention and 42 (46%) underwent ≥2 interventions. Twenty-five subjects (27%) died or underwent lung transplant 5.8 months (interquartile range [IQR] 1.1, 15.3) after diagnosis. There was no difference in age at diagnosis or mortality based on presence of CHD or prematurity. PVS diagnosis before age 6 months and greater than 1 pulmonary vein affected at diagnosis were associated with higher mortality (hazards ratio [HR] 3.4 (95% confidence interval 1.5, 7.5), P = 0.003, and HR 2.1 per additional vein affected (95% confidence interval 1.3, 3.4), P = 0.004, respectively). Survival in children with PVS is poor, independent of underlying CHD or prematurity. Younger age and greater number of veins affected at diagnosis are risk factors for worse outcome. Understanding causal mechanisms and development of treatment strategies are necessary to improve outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.