Evidence map›Paper›PMID 30278218›Full record

ArticleHuman immunology2018

Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA.

Eugene Moore, Alba Grifoni, Daniela Weiskopf, Veronique Schulten, Cecilia S Lindestam Arlehamn, Michael Angelo, John Pham, Shay Leary, John Sidney, David Broide and 5 more

Abstract read
In one paragraph

Article in Human immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  6. Review
  7. Comprehensive Analysis of CD4Frontiers in immunology · 2020
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Eugene MooreDivision of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA. Electronic address: emoore@lji.org.
Alba GrifoniDivision of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
Daniela WeiskopfDivision of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
Veronique SchultenDivision of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
Cecilia S Lindestam ArlehamnDivision of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
Michael AngeloDivision of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
John PhamDivision of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
Shay LearyInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia.
John SidneyDivision of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
David BroideDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
April FrazierDivision of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
Elizabeth PhillipsInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia; Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Simon MallalInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia; Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Steven J MackChildren's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Alessandro SetteDivision of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
La Jolla Institute for Immunology · USMurdoch University · AUUniversity of California San Diego · US

Funding

Inner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4M
Antigenic determinants of asthma-associated allergens for design of immunotherapy.R01AI077653 · NIAID · INDOOR BIOTECHNOLOGIES · PI MARTIN D. CHAPMAN, Maksymilian Chruszcz · 2009 to 2026
$9.5M
Understanding mechanisms in specific immunotherapy (SIT)U19AI100275 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SETTE, ALESSANDRO · 2012 to 2017
$8.1M
Towards the identification of biomarkers for pediatric milk allergyU19AI135731 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI VIJAYANAND, PANDURANGAN · 2018 to 2022
$5.6M
Integrated Exchange and Storage of Current- and Future-Generation Immunogenomic DataR01AI128775 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JILL Allison HOLLENBACH, STEVEN JOHN MACK · 2017 to 2026
$4.5M
Integrated Exchange & Storage of Current and Future-Generation Immunogenomic DataR01GM109030 · NIGMS · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI HOLLENBACH, JILL ALLISON, MACK, STEVEN JOHN · 2014 to 2016
$919k
NIAID NIH HHS HHSN272200700048CNIAID NIH HHS R01 AI077653NIAID NIH HHS R01 AI128775NIAID NIH HHS U19 AI100275NIAID NIH HHS U19 AI135731NIAID NIH HHS UM1 AI114271NIGMS NIH HHS R01 GM109030
6 · The paper itself

Abstract

DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 496 healthy adult donors from San Diego, California, to characterize allele frequencies in support of studies of T cell responses to common allergens. Deviations from Hardy Weinberg proportions were detected at each locus except A and C. Several alleles were found in more than 15% of individuals, including the class II alleles DPB1∗02:01, DPB1∗04:01, DQA1∗01:02, DQA1∗05:01, DQB1∗03:01, and the class I allele A∗02:01. Genotype data will be available in the Allele Frequencies Net Database (AFND 3562).

Indexed as

AdolescentAdultAllelesCaliforniaFemaleGene FrequencyGenotypeGenotyping TechniquesHistocompatibility TestingHLA-A AntigensHLA-B AntigensHLA-C AntigensHLA-DP AntigensHLA-DQ AntigensHLA-DR AntigensHumansHLA-A AntigensHLA-B AntigensHLA-C AntigensHLA-DP AntigensHLA-DQ AntigensHLA-DR AntigensAllergyHLA allelesHLA typingSan Diego, California

Identifiers

PMID30278218
PMCPMC6537871
OpenAlexW2892552003

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.