Observational studyMedicine and science in sports and exercise2019
Cardiorespiratory Fitness, Adiposity, and Heart Rate Variability: The Coronary Artery Risk Development in Young Adults Study.
Observational study in Medicine and science in sports and exercise, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of physical activity and heart rate variability in people with overweight and obesity: A systematic review.F1000Research · 2023Pooled it
- Association of Severe Obesity, Hypertension, and Physical Activity with 24 h Heart Rate Variability in Adults.Journal of cardiovascular development and disease · 2026Article
- Article
- Gender-specific impact of stress and adiposity on autonomic stress modulation in teachers.Frontiers in psychology · 2025Article
- Validation of a Time-to-Exhaustion-DerivedExercise, sport & movement · 2025Article
- Direct and indirect effects of adiposity on markers of autonomic nervous system activity in older adults.PloS one · 2024Article
- Heart Rate Variability and Cardiorespiratory Fitness in Youth Populations: The Impact of Heart Rate on Data Analysis.Journal of human kinetics · 2023Article
- Cardiorespiratory Fitness in the Prevention and Management of Cardiovascular Disease.Reviews in cardiovascular medicine · 2022Review
- Central markers of obesity affect heart rate variability independent of physical activity in young adults.Journal of family medicine and primary care · 2022Article
- Article
- Correlation between physical activity, cardiorespiratory fitness and heart rate variability among young overweight adults.Journal of Taibah University Medical Sciences · 2022Article
- A New Approach for Evaluation of Cardiovascular Fitness and Cardiac Responses to Maximal Exercise Test in Master Runners: A Cross-Sectional Study.Journal of clinical medicine · 2022Article
- Obesity, Nutrition and Heart Rate Variability.International journal of molecular sciences · 2021Review
- Estimated Cardiorespiratory Fitness Attenuates the Impacts of Sarcopenia and Obesity on Non-Alcoholic Fatty Liver in Korean Adults.International journal of environmental research and public health · 2020Article
- MOTS-c: an equal opportunity insulin sensitizer.Journal of molecular medicine (Berlin, Germany) · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeThe importance of cardiorespiratory fitness versus adiposity in determining heart rate variability (HRV) is unclear.
methodsFrom the Coronary Artery Risk Development in Young Adults study, an observational cohort study, we included 2316 participants (mean age = 45.2 ± 3.6 yr at year 20, 57% female, 43% Black) with HRV measured in 2005-2006 (year 20) and graded exercise test duration (GXTd) and adiposity measures (body mass index and waist circumference) obtained in 1985-1986 (baseline) and 2005-2006. HRV measures (SD of all normal RR intervals [SDNN] and square root of the mean value of the squares of differences between all successive RR intervals [RMSSD]) were obtained from resting 30-s 12-lead ECG. Cross-sectional associations between GXTd, adiposity, and HRV were assessed at year 20. Longitudinal changes in GXTd and adiposity measures were categorized as ≥10% increase, <10% change (no change), or ≥10% decrease. We used multivariable logistic regression to assess associations of GXTd and adiposity measures with unfavorable versus more favorable HRV (lower 25th percentile vs upper 75th percentile).
resultsA 1-SD increment in GXTd was associated with 22% and 32% lower odds of unfavorable SDNN and RMSSD, respectively; associations remained significant after adjustment for adiposity. A 1-SD increment in adiposity measures was associated with 16%-28% higher odds of unfavorable RMSSD; associations were not significant after adjustment for GXTd. Compared with no change/increase in GXTd, longitudinal decrease in GXTd was significantly associated with 55% and 94% higher odds of unfavorable SDNN and RMSSD, respectively, at year 20. These associations remained significant after adjusting for adiposity.
conclusionCardiorespiratory fitness may be a stronger determinant of HRV than adiposity. Intervention studies are needed to better determine the differential effects of improved cardiorespiratory fitness versus weight loss on HRV.
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