ArticleHuman brain mapping2018
Shifted balance of dorsal versus ventral striatal communication with frontal reward and regulatory regions in cannabis-dependent males.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature.Psychopharmacology · 2022Pooled it
- Brain network dysfunctions in addiction: a meta-analysis of resting-state functional connectivity.Translational psychiatry · 2022Pooled it
- Common and separable neural alterations in substance use disorders: A coordinate-based meta-analyses of functional neuroimaging studies in humans.Human brain mapping · 2020Pooled it
- No differences in inhibitory control or prefrontal activation during a cannabis cue stop-signal task across CUDIT-R-defined CUD-risk groups.Psychopharmacology · 2026Article
- Review
- No differences in neural responses or performance during cannabis cue-specific inhibitory control tasks between recreational cannabis users and non-users: Insights from fNIRS.Journal of psychopharmacology (Oxford, England) · 2026Article
- Behavioral addictions and their reciprocal associations with each other, substance use disorders, and mental health problems: Findings from a longitudinal cohort study of young Swiss men.Journal of behavioral addictions · 2025Article
- Abnormal ventromedial-to-dorsolateral hierarchical topography of striatal circuits in cocaine use disorder and its modulations by brain stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Unveiling Diverse Trajectories of Internet Addiction and the Influence of Family Environment and Obsessive Beliefs: Multi-Wave Longitudinal Study With Growth Mixed Model.Journal of medical Internet research · 2025Article
- The role of sex in the association between cannabis use disorder and resting-state functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Frontostriatal Networks Undergo Functional Specialization during Adolescence That Follows a Ventral-Dorsal Gradient: Developmental Trajectories and Longitudinal Associations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Obesity-related alterations of intrinsic functional architecture: a resting-state fMRI study based on the human connectome project.Frontiers in nutrition · 2025Article
- Screen use in children - two sides of the coin: a critical narrative review.Dementia & neuropsychologia · 2025Review
- Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood.Developmental cognitive neuroscience · 2024Article
- Biomarkers of Internet Gaming Disorder-A Narrative Review.Journal of clinical medicine · 2024Review
- A neurofunctional signature of subjective disgust generalizes to oral distaste and socio-moral contexts.Nature human behaviour · 2024Article
- Investigating sex differences and age of onset in emotion regulation, executive functioning, and cannabis use in adolescents and young adults.Journal of cannabis research · 2024Article
- Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals.The international journal of neuropsychopharmacology · 2023Article
- Critical tests of fuzzy trace theory in brain and behavior: uncertainty across time, probability, and development.Cognitive, affective & behavioral neuroscience · 2023Article
- Implications of neuroimaging findings in addiction.Psychoradiology · 2023Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transition from voluntary to addictive behavior is characterized by a loss of regulatory control in favor of reward driven behavior. Animal models indicate that this process is neurally underpinned by a shift in ventral-dorsal striatal control of behavior; however, this shift has not been directly examined in humans. The present resting state functional magnetic resonance imaging (fMRI) study employed a two-step approach to: (a) precisely map striatal alterations using a novel, data-driven network classification strategy combining intrinsic connectivity contrast with multivoxel pattern analysis and, (b) to determine whether a ventral to dorsal striatal shift in connectivity with reward and regulatory control regions can be observed in abstinent (28 days) male cannabis-dependent individuals (n = 24) relative to matched controls (n = 28). Network classification revealed that the groups can be reliably discriminated by global connectivity profiles of two striatal regions that mapped onto the ventral (nucleus accumbens) and dorsal striatum (caudate). Subsequent functional connectivity analysis demonstrated a relative shift between ventral and dorsal striatal communication with fronto-limbic regions that have been consistently involved in reward processing (rostral anterior cingulate cortex [ACC]) and executive/regulatory functions (dorsomedial prefrontal cortex [PFC]). Specifically, in the cannabis-dependent subjects, connectivity between the ventral striatum with the rostral ACC increased, whereas both striatal regions were uncoupled from the regulatory dorsomedial PFC. Together, these findings suggest a shift in the balance between dorsal and ventral striatal control in cannabis dependence. Similar changes have been observed in animal models and may promote the loss of control central to addictive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.