Evidence map›Paper›PMID 30277621›Full record

ArticleGlia2018

Syncytial isopotentiality: A system-wide electrical feature of astrocytic networks in the brain.

Conrad M Kiyoshi, Yixing Du, Shiying Zhong, Wei Wang, Anne T Taylor, Bangyan Xiong, Baofeng Ma, David Terman, Min Zhou

Open access · greenAbstract read
In one paragraph

Article in Glia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Membrane voltage multistability in coupled glial cells.bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Astrocyte Syncytium-A Biopower Grid System in the Brain.Journal of integrative neuroscience · 2024
    Article
  9. Review
  10. Article
  11. Electrophysiological In Vitro Study of Long-Range Signal Transmission by Astrocytic Networks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  12. Article
  13. Advances in the Electrophysiological Recordings of Long-Term Potentiation.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. Review
  17. CaFrontiers in cellular neuroscience · 2023
    Article
  18. A visualization pipeline forJournal of biomedical research · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Conrad M KiyoshiDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Yixing DuDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Shiying ZhongDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Wei WangDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Anne T TaylorDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Bangyan XiongDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Baofeng MaDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
David TermanDepartment of Mathematics, Ohio State University, Columbus, Ohio, USA.
Min ZhouDepartment of Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.ORCID 0000-0001-6249-2977
The Ohio State University Wexner Medical Center · USThe Ohio State University · USTongji University · CN

Funding

Ohio State University Neuroscience Center Core-Core EP30NS104177 · NINDS · OHIO STATE UNIVERSITY · PI BROWN, ANTHONY · 2017 to 2020
$1.9M
Involvement of astrocytic two-pore domain K+ channels in ischemic pathologyR01NS062784 · NINDS · ORDWAY RESEARCH INSTITUTE, INC. · PI ZHOU, MIN · 2010 to 2014
$1.7M
Astrocyte function at syncytial system levelsR56NS097672 · NINDS · OHIO STATE UNIVERSITY · PI ZHOU, MIN · 2016 to 2016
$385k
NINDS NIH HHS P30 NS104177NINDS NIH HHS P30NS104177NINDS NIH HHS R01 NS062784NINDS NIH HHS R56 NS097672NINDS NIH HHS R56NS097972NINDS NIH HHS RO1NS062784
6 · The paper itself

Abstract

Syncytial isopotentiality, resulting from a strong electrical coupling, emerges as a physiological mechanism that coordinates individual astrocytes to function as a highly efficient system in brain homeostasis. However, whether syncytial isopotentiality occurs selectively to certain brain regions or is universal to astrocytic networks remains unknown. Here, we have explored the correlation of syncytial isopotentiality with different astrocyte subtypes in various brain regions. Using a nonphysiological K

Indexed as

Aldehyde Dehydrogenase 1 FamilyAnimalsAnimals, NewbornAstrocytesBrainCells, CulturedConnexin 43FemaleGap JunctionsGreen Fluorescent ProteinsIn Vitro TechniquesIsoenzymesLysineMaleMembrane PotentialsMiceAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, mousebiocytinConnexin 43enhanced green fluorescent proteinGreen Fluorescent ProteinsIsoenzymesLysinePhosphopyruvate HydrataseRetinal DehydrogenaseSodiumastrocyteselectrical couplinggap junctionssyncytial isopotentiality

Identifiers

PMID30277621
PMCPMC8818325
OpenAlexW2890012531

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.