Evidence map›Paper›PMID 30277264›Full record

ArticleJournal of medical primatology2019

Comparison of sampling methods for profiling cervicovaginal microbiome in rhesus macaques.

Brian A Schmidt, Ronald Phillips, Matthew Rolston, Reben Raeman, Smita S Iyer

Abstract readComparative Study
In one paragraph

Article in Journal of medical primatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brian A SchmidtCenter for Comparative Medicine, University of California, Davis, California.
Ronald PhillipsCenter for Comparative Medicine, University of California, Davis, California.
Matthew RolstonHost Microbe Systems Biology Core, University of California, Davis, California.
Reben RaemanDepartment of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Smita S IyerCenter for Comparative Medicine, University of California, Davis, California.ORCID 0000-0002-8918-7005

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Targeting CD4 TFH cells to enhance HIV vaccine-induced humoral immunityK01OD023034 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IYER, SWAMINATHAN SMITA · 2016 to 2018
$1.0M
Role of CD4 T cells in the pathogenesis of non-alcoholic steatohepatitisK01DK110264 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAEMAN, REBEN · 2017 to 2021
$702k
Role of vaginal microbiome and metabolome in HIV vaccine efficacyR03AI138792 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IYER, SWAMINATHAN SMITA · 2018 to 2019
$157k
NIAID NIH HHS R03 AI138792NIDDK NIH HHS K01 DK110264NIH HHS K01 OD023034NIH HHS P51 OD011107
6 · The paper itself

Abstract

Cervicovaginal bacteria cause inflammation which in turn increases HIV risk. Profiling the cervicovaginal microbiome, therefore, is instrumental for vaccine development. We show that the microbiome profile captured by cervicovaginal lavage is comparable to samples obtained by vaginal swabs. Thus, lavage may serve as a sampling strategy in NHP vaccine studies.

Indexed as

MicrobiotaAnimalsBacteriaCervix UteriFemaleMacaca mulattaSpecimen HandlingVagina16S rRNAHIVlavageswab

Identifiers

PMID30277264
PMCPMC6326866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.