Evidence map›Paper›PMID 30277113›Full record

ArticleRenal failure2018

Changes in the inflammatory and oxidative stress markers during a single hemodialysis session in patients with chronic kidney disease.

B Sangeetha Lakshmi, N Harini Devi, M M Suchitra, P V L N Srinivasa Rao, V Siva Kumar

Open access · goldAbstract read
In one paragraph

Article in Renal failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 39 citations in OpenAlex.

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  6. Female Infertility in Chronic Kidney Disease.Diagnostics (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

B Sangeetha Lakshmia Department of Nephrology , Sri Venkateswara Institute of Medical Sciences , Tirupati, India.
N Harini Devib Department of Biochemistry , Sri Venkateswara Institute of Medical Sciences , Tirupati, India.
M M Suchitrab Department of Biochemistry , Sri Venkateswara Institute of Medical Sciences , Tirupati, India.
P V L N Srinivasa Raob Department of Biochemistry , Sri Venkateswara Institute of Medical Sciences , Tirupati, India.
V Siva Kumara Department of Nephrology , Sri Venkateswara Institute of Medical Sciences , Tirupati, India.
Sri Venkateswara Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5-20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation are related to the progress of CVD in HD patients. Several, but not all studies, reported that inflammatory and oxidative stress markers are increased during a single session of HD, mimicking changes that occur during acute immune activation. This study was taken up to evaluate the changes in the inflammatory and oxidative stress markers during a single HD session in patients with chronic kidney disease.

methodsTwenty-five ESRD patients on maintenance HD and 25 controls were included in the study. Blood samples were obtained from the patients before starting of hemodialysis (pre-HD) and after completion of hemodialysis (post-HD). The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group.

resultsThis study found increased levels of Pentraxin-3, hs-CRP, MDA, and decreased level of FRAP in HD patients compared to controls.

conclusionsHemodialysis procedure contributes to inflammation and oxidative stress.

Indexed as

Oxidative StressAdultAgedBiomarkersCardiovascular DiseasesCase-Control StudiesC-Reactive ProteinFemaleHumansIndiaInflammationKidney Failure, ChronicMaleMalondialdehydeMiddle AgedPentraxinsBiomarkersC-Reactive ProteinMalondialdehydePentraxinsSerum Amyloid P-ComponentCardiovascular diseasehemodialysisinflammationoxidative stress; Pentraxin-3

Identifiers

PMID30277113
PMCPMC6171457
OpenAlexW2895668342

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.