ReviewAllergy2019
Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments.
Review in Allergy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 3 syntheses or guidelines pooled it, 161 citations in OpenAlex.
- Pooled it
- Respiratory virus type to guide predictive enrichment approaches in the management of the first episode of bronchiolitis: A systematic review.Frontiers in immunology · 2022Pooled it
- Considerations on biologicals for patients with allergic disease in times of the COVID-19 pandemic: An EAACI statement.Allergy · 2020Guideline
- A randomized clinical trial to assess the effect of zinc and vitamin D supplementation in addition to hypertonic saline on treatment of acute bronchiolitis.BMC infectious diseases · 2022Trial
- Bacterial Mucosal Immunotherapy with MV130 Prevents Recurrent Wheezing in Children: A Randomized, Double-Blind, Placebo-controlled Clinical Trial.American journal of respiratory and critical care medicine · 2021Trial
- Effects of implementing a clinical scoring system on the management of infants with RSV bronchiolitis.Wiener klinische Wochenschrift · 2026Observational
- Clinical characteristics, risk factors, and pathogen spectrum of mixed infections in children withMicrobiology spectrum · 2026Article
- Epidemiological and Clinical Characteristics of Bronchiolitis and the Impact of RSV Infection: A Five-Year Study in a Tertiary Pediatric Center in Central Romania.Pediatric reports · 2026Article
- Global trends and advances in pediatric bronchiolitis treatment in the last two decades: a bibliometric analysis.Journal of thoracic disease · 2026Article
- Atelectasis secondary to two separate video-assisted thoracoscopic wedge resection of the lung lobe and pleurodesis under general anesthesia in the same patient: a case report.Frontiers in pediatrics · 2026Article
- Risk factors for progression to bronchitis or pneumonia in hospitalized children with human rhinovirus infection: a retrospective cohort study using machine learning.Frontiers in pediatrics · 2026Article
- Vitamin D disrupts NS1-TUFM interaction to suppress pathogenic mitophagy in RSV-induced mitochondrial injury of bronchial epithelial cells.Journal of microbiology (Seoul, Korea) · 2026Article
- Wheezing on admission: a marker for bronchiolitis severity and asthma development.Pediatric research · 2025Article
- Bronchial hyper-reactivity in young adults after hospitalisation for bronchiolitis in infancy.BMJ open respiratory research · 2025Article
- Association of fever and infections with the subsequent risk of atopic diseases in children with genetic susceptibility for T1D: Results from the TEDDY cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Characterizing the Genetics of Bronchiolitis by Viral Etiology: Is There a Shared Role in Asthma Development?The Journal of infectious diseases · 2025Article
- Mannose-binding lectin insufficiency is associated with airway Haemophilus colonization and a higher risk of post-RSV bronchiolitis recurrent wheezing.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Article
- Long Term Sequelae of Mild RSV Infections in Healthy Children Aged 0-3 Years in the Primary Care Setting-A Prospective Two Year Follow Up Observational Study.Journal of medical virology · 2025Observational
- Systemic IL-10 and IFN-γ Levels in Respiratory Syncytial Virus- and Rhinovirus-Infected Bulgarian Children with Acute Bronchiolitis and Their Impact on Clinical Manifestation.Pathogens (Basel, Switzerland) · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 11 institutions in 9 countries.
Funding
Abstract
Current data indicate that the "bronchiolitis" diagnosis comprises more than one condition. Clinically, pathophysiologically, and even genetically three main clusters of patients can be identified among children suffering from severe bronchiolitis (or first wheezing episode): (a) respiratory syncytial virus (RSV)-induced bronchiolitis, characterized by young age of the patient, mechanical obstruction of the airways due to mucus and cell debris, and increased risk of recurrent wheezing. For this illness, an effective prophylactic RSV-specific monoclonal antibody is available; (b) rhinovirus-induced wheezing, associated with atopic predisposition of the patient and high risk of subsequent asthma development, which may, however, be reversed with systemic corticosteroids in those with severe illness; and (c) wheeze due to other viruses, characteristically likely to be less frequent and severe. Clinically, it is important to distinguish between these partially overlapping patient groups as they are likely to respond to different treatments. It appears that the first episode of severe bronchiolitis in under 2-year-old children is a critical event and an important opportunity for designing secondary prevention strategies for asthma. As data have shown bronchiolitis cannot simply be diagnosed using a certain cutoff age, but instead, as we suggest, using the viral etiology as the differentiating factor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.