Evidence map›Paper›PMID 30276802›Full record

ArticleBritish journal of pharmacology2018

Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594: a novel fluorescent probe for the N/OFQ (NOP) receptor.

M F Bird, R Guerrini, J M Willets, J P Thompson, G Caló, D G Lambert

Open access · hybridAbstract read
In one paragraph

Article in British journal of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

M F BirdDepartment of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, Leicester Royal Infirmary, University of Leicester, Leicester, UK.
R GuerriniDepartment of Chemical and Pharmaceutical Sciences and LTTA, University of Ferrara, Ferrara, Italy.
J M WilletsDepartment of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID 0000-0003-4546-4469
J P ThompsonDepartment of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, Leicester Royal Infirmary, University of Leicester, Leicester, UK.
G CalóDepartment of Medical Sciences, Section of Pharmacology and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy.
D G LambertDepartment of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, Leicester Royal Infirmary, University of Leicester, Leicester, UK.ORCID 0000-0003-4769-8090
University of Leicester · GBUniversity of Ferrara · IT

Funding

Biotechnology and Biological Sciences Research Council BB/N000188/1
6 · The paper itself

Abstract

background and purposeThe nociceptin/orphanin FQ (N/OFQ) receptor (NOP) is a member of the opioid receptor family and is involved in a number of physiological responses, pain and immune regulation as examples. In this study, we conjugated a red fluorophore-ATTO594 to the peptide ligand N/OFQ (N/OFQ EXPERIMENTAL APPROACH: We assessed N/OFQ KEY

resultsN/OFQ CONCLUSIONS AND IMPLICATIONS: In the absence of validated NOP receptor antibodies and issues surrounding the use of radiolabels (especially in low expression systems), these data indicate the utility of N/OFQ

Indexed as

AnimalsCells, CulturedCHO CellsCricetulusFluorescent DyesHEK293 CellsHumansNeutrophilsNociceptinOpioid PeptidesReceptors, OpioidFluorescent DyesNociceptinOpioid PeptidesReceptors, Opioid

Identifiers

PMID30276802
PMCPMC6255954
OpenAlexW2889721340

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.