Evidence map›Paper›PMID 30276618›Full record

Observational studyJournal of cardiovascular translational research2018

Impact of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio on 5-Year Clinical Outcomes of Patients with Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention.

Edoardo Bressi, Fabio Mangiacapra, Elisabetta Ricottini, Ilaria Cavallari, Iginio Colaiori, Giuseppe Di Gioia, Antonio Creta, Marialessia Capuano, Michele Mattia Viscusi, Germano Di Sciascio

Abstract readComparative StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of cardiovascular translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  20. Lipoprotein(a), Immunity, and Inflammation in Polyvascular Atherosclerotic Disease.Journal of cardiovascular development and disease · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Edoardo BressiDepartment of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Fabio MangiacapraDepartment of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy. f.mangiacapra@unicampus.it.ORCID 0000-0002-3505-0716
Elisabetta RicottiniDepartment of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Ilaria CavallariDepartment of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Iginio ColaioriDepartment of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Giuseppe Di GioiaDepartment of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Antonio CretaDepartment of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Marialessia CapuanoDepartment of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Michele Mattia ViscusiDepartment of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.
Germano Di SciascioDepartment of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200, 00128, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prognostic role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with stable coronary artery disease (CAD) is still unclear. We enrolled 500 patients undergoing elective percutaneous coronary intervention (PCI). Blood samples were drawn prior to PCI for NLR and PLR calculation. Major adverse clinical events (MACE), which included death, myocardial infarction (MI), and target vessel revascularization (TVR), were recorded up to 5 years. Patients in the higher tertile of NLR presented higher Kaplan-Meier estimates of MACE (26.0% vs. 16.9% in tertile 2 vs. 14.3% in tertile 1; p = 0.042) and death (12.0% vs 6.9% in tertile 2 vs. 4.6% in tertile 1; p = 0.040), whereas there were no significant differences in the estimates of MI and TVR. NLR in the higher tertile was an independent predictor of MACE (HR 1.65, 95% CI 1.07-2.55, p = 0.024). No significant difference was observed across tertiles of PLR. Unlike PLR, elevated pre-procedural NLR is associated with an increased risk of 5-year clinical adverse events.

Indexed as

LymphocytesNeutrophilsPercutaneous Coronary InterventionAgedBiomarkersCoronary Artery DiseaseFemaleHumansLymphocyte CountMaleMiddle AgedPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsTime FactorsBiomarkersAtherosclerosisCoronary artery diseaseInflammationPlatelets

Identifiers

PMID30276618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.