ArticleCognitive, affective & behavioral neuroscience2018
Motivational deficits in schizophrenia relate to abnormalities in cortical learning rate signals.
Article in Cognitive, affective & behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Neurofunctional representations of instrumental learning in psychosis: a meta-analysis of neuroimaging studies.Psychological medicine · 2025Pooled it
- Arousal shapes motivation: an integrative framework for understanding motivational deficits.Translational psychiatry · 2026Review
- Exploring the relationship between frequent cannabis use, belief updating under uncertainty and psychotic-like symptoms.Frontiers in psychiatry · 2024Article
- Reinforcement learning deficits exhibited by postnatal PCP-treated rats enable deep neural network classification.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Neural Circuitry of Salience and Reward Processing in Psychosis.Biological psychiatry global open science · 2023Review
- Models of Dynamic Belief Updating in Psychosis-A Review Across Different Computational Approaches.Frontiers in psychiatry · 2022Review
- Acute and Lifetime Stress and Psychotic Illness: The Roles of Reward and Salience Networks.Journal of psychiatry and brain science · 2022Article
- Relative salience signaling within a thalamo-orbitofrontal circuit governs learning rate.Current biology : CB · 2021Article
- Unlocking the reinforcement-learning circuits of the orbitofrontal cortex.Behavioral neuroscience · 2021Article
- The Role of Executive Function in Shaping Reinforcement Learning.Current opinion in behavioral sciences · 2021Article
- The Reward-Complexity Trade-off in Schizophrenia.Computational psychiatry (Cambridge, Mass.) · 2021Article
- Disruption of Nrxn1α within excitatory forebrain circuits drives value-based dysfunction.eLife · 2020Article
- Striatal Dopamine and Reward Prediction Error Signaling in Unmedicated Schizophrenia Patients.Schizophrenia bulletin · 2020Article
- Differential Effects of Psychotic Illness on Directed and Random Exploration.Computational psychiatry (Cambridge, Mass.) · 2020Article
- Impaired Expected Value Computations in Schizophrenia Are Associated With a Reduced Ability to Integrate Reward Probability and Magnitude of Recent Outcomes.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Individuals from across the psychosis spectrum display impairments in reinforcement learning. In some individuals, these deficits may result from aberrations in reward prediction error (RPE) signaling, conveyed by dopaminergic projections to the ventral striatum (VS). However, there is mounting evidence that VS RPE signals are relatively intact in medicated people with schizophrenia (PSZ). We hypothesized that, in PSZ, reinforcement learning deficits often are not related to RPE signaling per se but rather their impact on learning and behavior (i.e., learning rate modulation), due to dysfunction in anterior cingulate and dorsomedial prefrontal cortex (dmPFC). Twenty-six PSZ and 23 healthy volunteers completed a probabilistic reinforcement learning paradigm with occasional, sudden, shifts in contingencies. Using computational modeling, we found evidence of an impairment in trial-wise learning rate modulation (α) in PSZ before and after a reinforcement contingency shift, expressed most in PSZ with more severe motivational deficits. In a subsample of 22 PSZ and 22 healthy volunteers, we found little evidence for between-group differences in VS RPE and dmPFC learning rate signals, as measured with fMRI. However, a follow-up psychophysiological interaction analysis revealed decreased dmPFC-VS connectivity concurrent with learning rate modulation, most prominently in individuals with the most severe motivational deficits. These findings point to an impairment in learning rate modulation in PSZ, leading to a reduced ability to adjust task behavior in response to unexpected outcomes. At the level of the brain, learning rate modulation deficits may be associated with decreased involvement of the dmPFC within a greater RL network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.