ArticleNeurocritical care2019
Venous Thromboembolism Prophylaxis in Neurocritical Care Patients: Are Current Practices, Best Practices?
Article in Neurocritical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early Versus Late Initiation of Chemical Venous Thromboembolism Prophylaxis in Adult Patients with Severe Traumatic Brain Injury: A Systematic Review and Meta-analysis.Neurocritical care · 2026Pooled it
- Prevalence, characteristics, and risk factors of venous thromboembolism in patients with brain tumor undergoing craniotomy: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Perceptions and implementation challenges of venous thromboembolism prevention among neurosurgery operating room nurses: a descriptive qualitative study.BMC nursing · 2026Article
- Venous Thromboembolism Prophylaxis in the Neurocritically Ill Population.Journal of clinical medicine · 2025Review
- Effect of Enhanced Recovery After Surgery compliance on postoperative venous thromboembolism.BJS open · 2025Article
- Venous thromboembolism prophylaxis practices in hematology/oncology patients admitted to neurological intensive care units.Frontiers in cardiovascular medicine · 2025Article
- Application of artificial neural network in daily prediction of bleeding in ICU patients treated with anti-thrombotic therapy.BMC medical informatics and decision making · 2023Article
- Chemical versus Mechanical and Chemical Venous Thromboembolism Prophylaxis in Neurocritically Ill Patients: A Cohort Study.Clinical pharmacology : advances and applications · 2023Article
- Predictors of deep-vein thrombosis in subarachnoid hemorrhage: a retrospective analysis.Acta neurochirurgica · 2020Article
- A multicentre controlled pre-post trial of an implementation science intervention to improve venous thromboembolism prophylaxis in critically ill patients.Intensive care medicine · 2019Article
- Cost-Effective Machine Learning Based Clinical Pre-Test Probability Strategy for DVT Diagnosis in Neurological Intensive Care Unit.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesVenous thromboembolism (VTE) is a leading cause of preventable, in-hospital deaths; critically ill patients have a higher risk. Effective and efficient strategies to prevent VTE exist; however, neurocritical care patients present unique challenges due to competing risk of bleeding. The objective of this study was to examine current VTE prophylaxis practices among neurocritical care patients, concordance with guideline-recommended care, and the association with clinical outcomes.
methodsThis retrospective cohort study of patients admitted to ten adult, medical-surgical and neurological intensive care units (ICUs) in nine hospitals between 2014 and 2017 using administrative and clinical data. Neurocritical care patients were classified based on the primary admission diagnosis. Concordance with guideline-recommended care was evaluated using recommendations from recent guidelines.
results20.0% of 23,191 patients were classified as neurocritical care. Among neurocritical care patients, pharmacological VTE prophylaxis was administered on 60.9% of all ICU days, mechanical VTE prophylaxis on 46.9%, and no VTE prophylaxis on 12.2% of all ICU days. Type of VTE prophylaxis was associated with sex, neurological diagnosis, and invasive neurological monitoring. Fifty-six percentage of ICU days were guideline concordant but concordance varied by recommendation (range 6-100%) and by type of VTE prophylaxis recommended (p = 0.05); among patients where guidelines recommended use of pharmacologic prophylaxis, care was concordant 26.6% of ICU days, whereas for mechanical prophylaxis it was concordant 80.5% of ICU days. There was an overall improvement in guideline concordance on 2.3% of ICU days after the publication of the Society of Neurocritical Care guideline (p = 0.005).
conclusionsNeurocritical care patients commonly receive mechanical VTE prophylaxis despite guidelines recommending the use of pharmacological VTE prophylaxis. Our findings suggest uncertainty around best VTE prophylaxis practices for neurocritical care patients remains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.