ArticleEndocrine2019
Posterior pituitary tumours: the spectrum of a unique entity. A clinical and histological study of a large case series.
Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Granular cell tumors of the sellar region: what should be done after subtotal resection? A systematic review.Pituitary · 2020Pooled it
- Primary tumors of the posterior pituitary: A systematic review.Reviews in endocrine & metabolic disorders · 2019Pooled it
- Spindle cell oncocytoma: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- A third ventricular floor-associated TTF-1-positive posterior pituitary tumor: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Pituicytoma in the third ventricle suggesting a third ventricular floor origin: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Posterior Pituitary and Hypothalamic Neuronal Tumors in the 5th WHO Classification: Molecular Insights, Diagnostic Markers, and Clinical Management.International journal of molecular sciences · 2026Review
- Preoperative Prediction of Non-functional Pituitary Neuroendocrine Tumors and Posterior Pituitary Tumors Based on MRI Radiomic Features.Journal of imaging informatics in medicine · 2026Article
- Article
- Histopathological Types, Clinical Presentation, Imaging Studies, Treatment Strategies, and Prognosis of Posterior Pituitary Tumors: An Updated Review.Journal of clinical medicine · 2025Review
- Pituitary Spindle Cell Oncocytoma: More than a Grade 1 Tumor?Neurology international · 2025Article
- Posterior transpetrosal approach to a suprasellar retroinfundibular pituicytoma: A case report and comprehensive literature review.Brain & spine · 2025Article
- Posterior pituitary tumors and other rare entities involving the pituitary gland.Brain pathology (Zurich, Switzerland) · 2025Review
- Oncocytic pituicytoma in a patient with Cushing's disease: a case report and narrative literature review.Frontiers in endocrinology · 2025Review
- Intraventricular pituicytoma: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Treatment modalities and outcomes of granular cell tumors and spindle cell oncocytomas of the pituitary gland: an analysis of two national cancer databases.Acta neurochirurgica · 2024Article
- Pituicytoma Associated with Suspected Cushing's Disease: Two Case Reports and a Literature Review.Journal of clinical medicine · 2022Article
- Recommendation to improve the WHO classification of posterior pituitary tumors as a unique entity: evidence from a large case series.Endocrine connections · 2022Article
- Epidemiology of common and uncommon adult pituitary tumors in the U.S. according to the 2017 World Health Organization classification.Pituitary · 2022Article
- Posterior pituitary tumours: patient outcomes and determinants of disease recurrence or persistence.Endocrine connections · 2021Article
- Review
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn 2017, the WHO established that pituicytoma, granular cell tumour (GCT) and spindle cell oncocytoma (SCO) are posterior pituitary tumours (PPT). Recent data suggests that these tumours probably arise from the pituicytes and may constitute a spectrum of a unique histopathological entity. Our aim is to report the clinical findings and surgical outcomes of 16 patients with PPT. We also evaluated the tissue specimens available in light of current knowledge.
methodCross-sectional study with retrospective data.
resultsPPT were 7 pituicytomas, 3 GCT and 6 SCO. Patients mean age was 55 years old and 75% were female. Basal hormonal study showed hyperprolactinemia (43.7%) and hypopituitarism (37.5%). There was no case of diabetes insipidus (DI). MRI showed sellar/suprasellar masses with mean size of 19.7mm. PPT was not suspected in any patient. Fifteen patients underwent surgery and complications were common: 20% had perioperative bleeding (one patient died because of a massive haemorrhage), 57.1% hypopituitarism, 35.7% permanent DI and 21.4% underwent a second surgery. Pathological findings shown positivity for thyroid transcription factor 1, vimentin and negativity for cytokeratin and chromogranin A in all specimens evaluated. S100 protein was positive in 88.8% of tumours. Ki67 was ≥ 3% in 66.6% and ranged from 4-7% in SCO.
conclusionPPT have similar histology, clinical features and are frequently misdiagnosed as nonfunctioning pituitary tumours. However, post-surgical complications including haemorrhage are common. A high clinical suspicion is needed to presume the diagnosis prior surgery and diminish the high morbidity of these tumours.
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