Observational studyDigestive diseases and sciences2019
Creeping Fat Assessed by Small Bowel MRI Is Linked to Bowel Damage and Abdominal Surgery in Crohn's Disease.
Observational study in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Semi-Automatic Assessment of Crohn's Disease Activity by Combined Analysis of Bowel Lesions and Creeping Fat.Magnetic resonance in medicine · 2026Article
- The role of lipid metabolism and creeping fat in disease assessment and prediction for Crohn's disease.Frontiers in immunology · 2026Review
- Article
- Can Creeping Fat Be a Prognostic Factor in Crohn's Disease?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Therapeutic Drug Monitoring in Special Circumstances in Inflammatory Bowel Disease.Journal of clinical medicine · 2025Review
- Creeping fat is associated with transmural healing in patients with Crohn's disease receiving ustekinumab.Insights into imaging · 2025Article
- Mesenteric fat proliferation on magnetic resonance enterography is a predictor of long-term disease complications in crohn's disease.BMC gastroenterology · 2025Article
- Magnetic resonance enterography for predicting poor prognosis in Crohn's disease: a systematic review with meta-analysis.Therapeutic advances in gastroenterology · 2025Review
- The mesenteric adipokine SFRP5 alleviated intestinal epithelial apoptosis improving barrier dysfunction in Crohn's disease.iScience · 2024Article
- Gut microbiota and mesenteric adipose tissue interactions in shaping phenotypes and treatment strategies for Crohn's disease.World journal of gastroenterology · 2024Article
- Perivascular Adipose Tissue Becomes Pro-Contractile and Remodels in an IL10International journal of molecular sciences · 2024Article
- CT energy spectral parameters of creeping fat in Crohn's disease and correlation with inflammatory activity.Insights into imaging · 2024Article
- Mathematical Models Including microRNA Levels of Mesenteric Adipose Tissue May Predict Postoperative Relapse in Crohn's Disease Patients.Gastro hep advances · 2024Article
- Creeping Fat in Crohn's Disease-Surgical, Histological, and Radiological Approaches.Journal of personalized medicine · 2023Review
- Mesenteric Adipose Tissue-Derived Klebsiella variicola Disrupts Intestinal Barrier and Promotes Colitis by Type VI Secretion System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Body Composition Predictors of Complicated Crohn's Disease.Digestive diseases (Basel, Switzerland) · 2023Article
- Creeping fat formation and interaction with intestinal disease in Crohn's disease.United European gastroenterology journal · 2022Review
- Serial Changes in Body Composition and the Association with Disease Activity during Treatment in Patients with Crohn's Disease.Diagnostics (Basel, Switzerland) · 2022Article
- Role of mesenteric component in Crohn's disease: A friend or foe?World journal of gastrointestinal surgery · 2021Review
- Adults with Crohn's disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission.Scientific reports · 2021Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCrohn's disease (CD) leads to bowel damage and surgery in a significant proportion of patients.
aimsThe aim of the study was to evaluate the predictive value of creeping fat assessed by small bowel MRI in CD patients.
methodsCD patients undergoing small bowel MRI were included in a retrospective observational cohort study. Clinical findings were extracted and correlated with radiological outcome measures. Logistic regression analysis was performed to assess predictors associated with a complicated course and surgery within 2 years and long-term follow-up.
resultsNinety patients (49% female, median follow-up 93 months) were included. Creeping fat was identified in 21.1%. Of these patients, 68% and 79% developed bowel damage (p < .05) and 42% and 63% of patients revealing creeping fat underwent surgery within 2 years following MRI and total follow-up, respectively. The presence of creeping fat [odds ratio (OR) 4.0], inflammatory stenosis (OR 3.7), multisegmental (small) bowel (OR 4.5 and 3.8), and proximal small bowel inflammation (OR 5.0) were associated with inferior outcome (p < .05) in a univariate analysis. Creeping fat was independently associated with a disabling course, bowel damage, and surgery (OR 3.5 each, p < .05) in a multivariate analysis model.
conclusionCreeping fat identified by small bowel MRI is associated with a complicated course and abdominal surgery in CD. Our data adds evidence that small bowel MRI facilitates risk stratification in order to define a patient at risk of disease-related complications in CD. [DRKS00011727, www.germanctr.de/ ].
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