Evidence map›Paper›PMID 30276555›Full record

ArticleClinical drug investigation2018

Signal Detection Between Fluoroquinolone Use and the Risk of Rhegmatogenous Retinal Detachment: Sequence Symmetry Analysis Using Nationwide South Korean Healthcare Database Between 2004 and 2015.

Yeon-Hee Baek, Sang Jun Park, Sohyun Jeong, In-Sun Oh, Han Eol Jeong, Kyu Hyung Park, Ju-Young Shin

Abstract read
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In one paragraph

Article in Clinical drug investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Safety of fluoroquinolones.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yeon-Hee BaekSchool of Pharmacy, Sungkyunkwan University, Suwon, South Korea.ORCID http://orcid.org/0000-0001-9597-6310
Sang Jun ParkDepartment of Ophthalmology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, South Korea.ORCID http://orcid.org/0000-0003-0542-2758
Sohyun JeongSchool of Pharmacy, Gachon University, Incheon, South Korea.
In-Sun OhSchool of Pharmacy, Sungkyunkwan University, Suwon, South Korea.ORCID http://orcid.org/0000-0001-9878-4779
Han Eol JeongSchool of Pharmacy, Sungkyunkwan University, Suwon, South Korea.ORCID http://orcid.org/0000-0001-6678-0941
Kyu Hyung ParkDepartment of Ophthalmology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, South Korea.
Ju-Young ShinSchool of Pharmacy, Sungkyunkwan University, Suwon, South Korea. shin.jy@skku.edu.ORCID http://orcid.org/0000-0003-1010-7525

Funding

National Research Foundation of Korea NRF-2017K1A3A1A12073341Seoul National University Hospital 14-2017-009
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe association between fluoroquinolone and rhegmatogenous retinal detachment (RRD) has been controversial as a result of inconsistent findings. We set out to detect a possible association of fluoroquinolone use and risk of RRD, using sequence symmetry analysis (SSA).

methodsWe conducted an SSA, case-only design, using a Korean nationwide healthcare database between 2004 and 2015. Exposure was defined as new fluoroquinolone use and outcome as an incident RRD, defined by a diagnosis of RRD (ICD-10: "H33.0") or surgery for RRD. Pairs of exposure and RRD within a 1-year time-window were included. The sequence ratio (SR) was calculated by the ratio of the number of patients prescribed with exposure first and diagnosed with RRD second divided by the number of patients diagnosed with RRD first and prescribed with exposure second. SR was adjusted (aSR) for underlying trends and 95% confidence intervals (CIs) were calculated. In order to observe whether the estimated ratio stabilized over time, we did repeated time-sequential analyses with the cumulative data starting from the 3-year period 2004-2006 to 2015.

resultsFluoroquinolone use had a greater association with RRD as compared with other antibiotics [fluoroquinolone: 5234 pairs; aSR = 1.70 (95% CI 1.61-1.80), first-generation cephalosporin: 4139 pairs; aSR = 1.39 (95% CI 1.31-1.80), second-generation cephalosporin: 5914 pairs; aSR = 1.31 (95% CI 1.24-1.38), third-generation cephalosporin: 3650 pairs; aSR = 0.88 (95% CI 0.83-0.95), extended-spectrum penicillin: 4823 pairs; aSR = 1.29 (95% CI 1.31-1.47), macrolides: 4115 pairs; aSR = 1.31 (95% CI 1.24-1.39)]. Time-sequential analyses supported the association between fluoroquinolone and RRD.

conclusionsOur detection suggests a possible association between fluoroquinolone use and RRD. However, possible overestimation and reverse causality bias may have influenced our findings due to the limitation of an SSA design.

Indexed as

AdultAgedAnti-Bacterial AgentsDatabases, FactualDelivery of Health CareFemaleFluoroquinolonesHumansMaleMiddle AgedNational Health ProgramsRepublic of KoreaRetinal DetachmentRisk FactorsAnti-Bacterial AgentsFluoroquinolones

Identifiers

PMID30276555

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.