Evidence map›Paper›PMID 30276544›Full record

ArticleActa neurochirurgica2019

Pharmacological management of post-traumatic seizures in adults: current practice patterns in the UK and the Republic of Ireland.

Harry Mee, Angelos G Kolias, Aswin Chari, Ari Ercole, Fiona Lecky, Carole Turner, Catrin Tudur-Smith, Jonathan Coles, Fahim Anwar, Antonio Belli and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neurochirurgica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, "M-type") KJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  10. Article
  11. Head injury in the elderly - an overview for the physician.Clinical medicine (London, England) · 2019
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 1 country.

Harry MeeDepartment of Clinical Neurosciences, University of Cambridge & Addenbrooke's Hospital, Cambridge, UK. harrymee@nhs.net.ORCID 0000-0002-1314-3962
Angelos G KoliasDepartment of Clinical Neurosciences, University of Cambridge & Addenbrooke's Hospital, Cambridge, UK.
Aswin ChariDepartment of Neurosurgery, Royal London Hospital, London, UK.
Ari ErcoleNeurosciences Critical Care Unit and Division of Anaesthesia, University of Cambridge & Addenbrooke's Hospital, Cambridge, UK.
Fiona LeckySchool of Health and Related Research, University of Sheffield, Sheffield, UK.
Carole TurnerDepartment of Clinical Neurosciences, University of Cambridge & Addenbrooke's Hospital, Cambridge, UK.
Catrin Tudur-SmithDepartment of Biostatistics, University of Liverpool, Merseyside, Liverpool, UK.
Jonathan ColesNeurosciences Critical Care Unit and Division of Anaesthesia, University of Cambridge & Addenbrooke's Hospital, Cambridge, UK.
Fahim AnwarDepartment of Clinical Neurosciences, University of Cambridge & Addenbrooke's Hospital, Cambridge, UK.
Antonio BelliDepartment of Neurosurgery, Queen Elizabeth Hospital, Birmingham, UK.
Mark ManfordDepartment of Clinical Neurosciences, University of Cambridge & Addenbrooke's Hospital, Cambridge, UK.
Timothy HamDepartment of Clinical Neurosciences, University of Cambridge & Addenbrooke's Hospital, Cambridge, UK.
Catherine McMahonDepartment of Neurosurgery, The Walton Centre, Liverpool, UK.
Diederik BultersDepartment of Neurosurgery, University Hospital Southampton, Southampton, UK.
Chris UffDepartment of Neurosurgery, Royal London Hospital, London, UK.
John S DuncanDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Mark H WilsonImperial Neurotrauma Centre, Department of Surgery & Cancer, Imperial College, London, UK.
Anthony G MarsonDepartment of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Peter J HutchinsonDepartment of Clinical Neurosciences, University of Cambridge & Addenbrooke's Hospital, Cambridge, UK.
University of Cambridge · GBUniversity of Liverpool · GBRoyal London Hospital · GBImperial College London · GBQueen Elizabeth Hospital Birmingham · GBUniversity College London · GBUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Sheffield · GB

Funding

Department of Health 12/35/57Department of Health HTA/13/15/02Department of Health II-C5-0715-20005Department of Health NIHR-RP-R3-12-013Medical Research Council G0502030Medical Research Council G0600986Medical Research Council G0601025Medical Research Council G1002277Medical Research Council G9439390
6 · The paper itself

Abstract

backgroundPatient selection for seizure prophylaxis after traumatic brain injury (TBI) and duration of anti-epileptic drug treatment for patients with early post-traumatic seizures (PTS), remain plagued with uncertainty. In early 2017, a collaborative group of neurosurgeons, neurologists, neurointensive care and rehabilitation medicine physicians was formed in the UK with the aim of assessing variability in current practice and gauging the degree of uncertainty to inform the design of future studies. Here we present the results of a survey of clinicians managing patients with TBI in the UK and Ireland. MATERIALS AND

methodsAn online survey was developed and piloted. Following approval by the Academic Committee of the Society of British Neurological Surgeons, it was distributed via appropriate electronic mailing lists.

resultsOne hundred and seventeen respondents answered the questionnaire, predominantly neurosurgeons (76%) from 30 (of 32) trauma-receiving hospitals in the UK and Ireland. Fifty-three percent of respondents do not routinely use seizure prophylaxis, but 38% prescribe prophylaxis for one week. Sixty percent feel there is uncertainty regarding the use of seizure prophylaxis, and 71% would participate in further research to address this question. Sixty-two percent of respondents use levetiracetam for treatment of seizures during the acute phase, and 42% continued for a total of 3 months. Overall, 90% were uncertain about the duration of treatment for seizures, and 78% would participate in further research to address this question.

conclusionThe survey results demonstrate the variation in practice and uncertainty in both described aspects of management of patients who have suffered a TBI. The majority of respondents would want to participate in future research to help try and address this critical issue, and this shows the importance and relevance of these two clinical questions.

Indexed as

AnticonvulsantsBrain Injuries, TraumaticDrug UtilizationHumansIrelandLevetiracetamSeizuresSurveys and QuestionnairesUnited KingdomAnticonvulsantsLevetiracetamAnti-epileptic medicationPost-traumatic seizuresSeizure prophylaxisTraumatic brain injury

Identifiers

PMID30276544
PMCPMC6407744
OpenAlexW2895129038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.