ReviewPediatric nephrology (Berlin, Germany)2019
Towards adulthood with a solitary kidney.
Review in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Fetal Multicystic Dysplastic Kidney and Its Effect on Post-natal Quality of Life: A Literature Review.Cureus · 2026Review
- When childhood anomalies grow up: adult-onset discovery of multicystic dysplastic kidney, a case report.BMC nephrology · 2026Article
- Clinical spectrum, outcome and impact of nephrectomy in critically-ill adult patients with emphysematous pyelonephritis: the PYELEMPHY observational retrospective multicenter Study.Annals of intensive care · 2026Article
- Unilateral Renal Agenesis: Prenatal Diagnosis and Postnatal Issues.Diagnostics (Basel, Switzerland) · 2025Review
- Children as Living Solid Organ Donors: Ethical Discussion and Model Hospital Policy Statement.The Journal of clinical ethics · 2025Article
- The rationale for nephron-sparing surgery in unilateral non-syndromic Wilms tumour.Pediatric nephrology (Berlin, Germany) · 2024Review
- Time to Change Our Viewpoints to Assess Renal Risks in Patients with Solitary Kidneys beyond Traditional Approaches?Journal of clinical medicine · 2023Article
- Beneficial effects of brief early life angiotensin-converting enzyme inhibition wane with time in sheep with solitary functioning kidney.Clinical science (London, England : 1979) · 2023Article
- Pediatric Small Renal Masses: Can Tumor Size Predict Histology and the Potential for Nephron-sparing Surgery?The Journal of urology · 2023Article
- Management of the congenital solitary kidney: consensus recommendations of the Italian Society of Pediatric Nephrology.Pediatric nephrology (Berlin, Germany) · 2022Review
- Salvation of a solitary kidney in a patient with grade IV renal trauma: a case report.Journal of trauma and injury · 2022Article
- Salt sensitivity of blood pressure in childhood and adolescence.Pediatric nephrology (Berlin, Germany) · 2022Review
- Prevalence of reflux nephropathy in Iranian children with solitary kidney: results of a multi-center study.BMC nephrology · 2022Article
- The spectrum of kidney function alterations in adolescents with a solitary functioning kidney.Pediatric nephrology (Berlin, Germany) · 2021Article
- Do children with solitary or hypofunctioning kidney have the same prevalence for masked hypertension?Pediatric nephrology (Berlin, Germany) · 2021Article
- Childhood risk factors for adulthood chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Review
- Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Selected Cytokines-Potential Biomarkers in Children with Solitary Functioning Kidney.Journal of clinical medicine · 2021Article
- Should we need more sensitive early diagnostic markers in children with congenital solitary functioning kidneys?Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Born with a solitary kidney: at risk of hypertension.Pediatric nephrology (Berlin, Germany) · 2020Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Around 1/1000 people have a solitary kidney. Congenital conditions mainly include multicystic dysplastic kidney and unilateral renal aplasia/agenesis; acquired conditions are secondary to nephrectomy performed because of urologic structural abnormalities, severe parenchymal infection, renal trauma, and renal or pararenal tumors. Children born with congenital solitary kidney have a better long-term glomerular filtration rate than those with solitary kidney secondary to nephrectomy later in life. Acute and chronic adaptation processes lead to hyperfiltration followed by fibrosis in the remnant kidney, with further risk of albuminuria, arterial hypertension, and impaired renal function. Protective measures rely on non-pharmacological renoprotection (controlled protein and sodium intake, avoidance/limitation of nephrotoxic agents, keeping normal body mass index, and limitation of tobacco exposure). Lifelong monitoring should include blood pressure and albuminuria assessment, completed by glomerular filtration rate (GFR) estimation in case of abnormal values. In the absence of additional risk factors to solitary kidney, such assessment can be proposed every 5 years. There is no current consensus for indication and timing of pharmacological intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.