Evidence map›Paper›PMID 30276516›Full record

ArticleClinical oral investigations2019

Microbial diversity in infections of patients with medication-related osteonecrosis of the jaw.

Matthias Zirk, Charlotte Wenzel, Johannes Buller, Joachim E Zöller, Max Zinser, Franziska Peters

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Matthias ZirkDepartment for Oral and Craniomaxillofacial and Plastic Surgery, University of Cologne, Kerpener Strasse, 62 50931, Cologne, Germany. matthias_zirk@yahoo.de.ORCID http://orcid.org/0000-0001-8776-0042
Charlotte WenzelDepartment for Oral and Craniomaxillofacial and Plastic Surgery, University of Cologne, Kerpener Strasse, 62 50931, Cologne, Germany.
Johannes BullerDepartment for Oral and Craniomaxillofacial and Plastic Surgery, University of Cologne, Kerpener Strasse, 62 50931, Cologne, Germany.
Joachim E ZöllerDepartment for Oral and Craniomaxillofacial and Plastic Surgery, University of Cologne, Kerpener Strasse, 62 50931, Cologne, Germany.
Max ZinserDepartment for Oral and Craniomaxillofacial and Plastic Surgery, University of Cologne, Kerpener Strasse, 62 50931, Cologne, Germany.
Franziska PetersDepartment of Dermatology, University of Cologne, Cologne, Germany.
University of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesA central role of infections in the treatment of MRONJ patients is widely accepted. An investigation of the MRONJ lesions' biofilms as potential pathogens seems logical. MATERIALS AND

methodsWe investigated the clinical data of our MRONJ patients who received surgery in advanced stage of the disease. Special attention was granted to the local colonizers harvested from osseous MRONJ specimens and submucosal putrid infections.

resultsEleven out of 71 patients presented a spontaneous onset of the disease and for 60 out of 71 patients a trigger was detected. Breast cancer (29.6%) and prostate cancer (22.5%) were the most frequent underlying disease for prescription of an antiresorptive therapy, mostly zoledronate. Submucosal soft tissue biofilms significantly differed from biofilms harvested from the MRONJ lesions bottom, yet the most frequent bacteria were equally present in both groups: Streptococcus species (spp.), Prevotella spp., Actinomyces spp., Veillonella spp., and Parvimonas micra. The cephalosporins, cefuroxime and cefotaxime, and ß-lactam antibiotics with ß-lactamase inhibitor revealed the greatest susceptibility for the detected bacteria.

conclusionThe bacteria from the submucosal areas and the bottom of the infected bone presented comparable susceptibility to the common antibiotics regimes. Streptococcus spp., Prevotella spp., and Veillonella spp. present a high abundance in MRONJ lesions beside Actinomyces spp. The MRONJ lesions bottom is in many cases not infected by Actinomyces spp. CLINICAL RELEVANCE: The removal of the necrotic bone reduces the variety of bacteria found in MRONJ lesions, in particular at the bottom of the lesion.

Indexed as

ActinomycesAgedAged, 80 and overBacterial InfectionsBisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsBreast NeoplasmsDiphosphonatesFemaleHumansMaleMiddle AgedPrevotellaProstatic NeoplasmsStreptococcusVeillonellaBone Density Conservation AgentsDiphosphonatesZoledronic AcidAntibiotic treatmentBone and soft tissue infectionsMRONJOsteonecrosis of the jawsPathogenic biofilmsRelevant pathogens

Identifiers

PMID30276516
OpenAlexW2895370088

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.