Evidence map›Paper›PMID 30276476›Full record

Trial reportEuropean journal of applied physiology2018

Dietary curcumin supplementation does not alter peripheral blood mononuclear cell responses to exertional heat stress.

Peter A Falgiano, Trevor L Gillum, Zach J Schall, Harrison R Strag, Matthew R Kuennen

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Article
  7. Exercise sustains the hallmarks of health.Journal of sport and health science · 2023
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Peter A FalgianoDepartment of Exercise Science, High Point University, One University Parkway, High Point, NC, 27268, USA.
Trevor L GillumDepartment of Kinesiology, California Baptist University, Riverside, CA, 92504, USA.
Zach J SchallDepartment of Exercise Science, High Point University, One University Parkway, High Point, NC, 27268, USA.
Harrison R StragDepartment of Exercise Science, High Point University, One University Parkway, High Point, NC, 27268, USA.
Matthew R KuennenDepartment of Exercise Science, High Point University, One University Parkway, High Point, NC, 27268, USA. mkuennen@highpoint.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCurcumin reduces gut barrier damage and plasma cytokine responses to exertional heat stress. However, the role of peripheral blood mononuclear cell (PBMC) in this response remains unclear. PURPOSE: This work investigated the effect of 3 days of 500 mg/day dietary curcumin supplementation on PBMC responses to exertional heat stress in non-heat acclimated humans.

methodsEight participants ran (65% VO

resultsAs compared to placebo, curcumin did not alter protein expression in PBMC (p > 0.05). However, in both study conditions at 1 h post-reductions were noted in TLR 4 (- 21.5%; p = 0.03), HSP70 (- 11.0%; p = 0.04), pAMPK (- 48.5%; p < 0.01), and SIRT1 (- 47.8%; p < 0.01). Remarkably, the ratio of pNF-κB to NF-κB was elevated in both conditions at this same timepoint (+ 75.4%; p = 0.02).

conclusionsInflammatory protein expression in PBMC did not differ between curcumin and placebo conditions. Downregulation of pAMPK/SIRT1 and release of HSP70 to the bloodstream may compensate for reduced TLR4, allowing PBMC to maintain inflammatory capacity and preventing an "open window" during the hours following hyperthermic exercise.

Indexed as

Physical ExertionAdolescentAnti-Inflammatory Agents, Non-SteroidalBiomarkersCurcuminDietary SupplementsFemaleHeat-Shock ResponseHeat Stress DisordersHSP72 Heat-Shock ProteinsHumansMaleMonocytesMyeloid Differentiation Factor 88NF-kappa BToll-Like Receptor 4Anti-Inflammatory Agents, Non-SteroidalBiomarkersCurcuminHSP72 Heat-Shock ProteinsMYD88 protein, humanMyeloid Differentiation Factor 88NF-kappa BTLR4 protein, humanToll-Like Receptor 4Dietary supplementExerciseHyperthermiaImmuneInflammationOpen window

Identifiers

PMID30276476

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.