ReviewBrain circulation
Cerebrovascular dysfunction with stress and depression.
Review in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 89 citations in OpenAlex.
- Article
- Neurovascular coupling and cerebrovascular reactivity: physiology, lifespan development, pathophysiology, and clinical relevance.Frontiers in physiology · 2026Review
- Exploring the effects of short-term forest bathing on anxious medical undergraduates' stressful emotions using near-infrared functional brain imaging and facial expression technology.Frontiers in psychology · 2026Article
- Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors.Cell stem cell · 2025Article
- Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.GeroScience · 2025Review
- Molecular Pathways of Endothelial Dysfunction Induced by Chronic Social Stress and Therapeutic Interventions.Journal of cardiovascular translational research · 2025Review
- Mid-life exposure to chronic stress accelerates cerebrovascular dysfunction and upregulates oxidative stress in Alzheimer's disease mice.Journal of Alzheimer's disease : JAD · 2025Article
- Developmental Trends of Metabolic Syndrome in the Past Two Decades: A Narrative Review.Journal of clinical medicine · 2025Review
- Decoding Alzheimer's Disease With Depression: Molecular Insights and Therapeutic Target.Journal of cellular and molecular medicine · 2025Article
- Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety.Nature communications · 2024Article
- Association of psychosocial state with subsequent risk of dementia: a prospective cohort study based on the UK Biobank.Alzheimer's research & therapy · 2024Article
- Chronic sleep fragmentation impairs brain interstitial clearance in young wildtype mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism.International journal of general medicine · 2024Review
- Association between stress-related disorders and the risk of dementia using the Korean National Sample Cohort: a matched cohort study.Scientific reports · 2023Article
- Hippocampal Connectivity with the Default Mode Network is Linked to Hippocampal Volume in the Clinical High Risk for Psychosis Syndrome and Healthy Individuals.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing.eLife · 2023Article
- CSF1R regulates schizophrenia-related stress response and vascular association of microglia/macrophages.BMC medicine · 2023Article
- Depression, stress and regional cerebral blood flow.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- The Wicked Relationship between Depression and Metabolic Syndrome.Clinical neuropsychiatry · 2023Review
- Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Maintenance of adequate tissue perfusion through a dense network of cerebral microvessels is critical for the perseveration of normal brain function. Regulation of the cerebral blood flow has to ensure adequate delivery of nutrients and oxygen with moment-to-moment adjustments to avoid both hypo- and hyper-perfusion of the brain tissue. Even mild impairments of cerebral blood flow regulation can have significant implications on brain function. Evidence suggests that chronic stress and depression elicits multifaceted functional impairments to the cerebral microcirculation, which plays a critical role in brain health and the pathogenesis of stress-related cognitive impairment and cerebrovascular events. Identifying the functional and structural changes to the brain that are induced by stress is crucial for achieving a realistic understanding of how related illnesses, which are highly disabling and with a large economic cost, can be managed or reversed. This overview discusses the stress-induced alterations in neurovascular coupling with specific attention to cerebrovascular regulation (endothelial dependent and independent vasomotor function, microvessel density). The pathophysiological consequences of cerebral microvascular dysfunction with stress and depression are explored.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.