ReviewBrain circulation
Facial nerve stimulation as a future treatment for ischemic stroke.
Review in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stimulating the Facial Nerve to Treat Ischemic Stroke: A Systematic Review.Frontiers in neurology · 2021Pooled it
- Sphenopalatine ganglion stimulation for the treatment of cerebrovascular ischemia.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Review
- Clinically relevant morphometric analysis of pterygopalatine fossa and its volumetric relationship with adjacent paranasal sinuses: a CT-based study.Oral radiology · 2024Article
- Therapeutic Induction of Collateral Flow.Translational stroke research · 2023Review
- Neural control of cerebral blood flow: scientific basis of scalp acupuncture in treating brain diseases.Frontiers in neuroscience · 2023Review
- Trigeminal Nerve Control of Cerebral Blood Flow: A Brief Review.Frontiers in neuroscience · 2021Review
- Regulation of Blood Flow in the Cerebral Posterior Circulation by Parasympathetic Nerve Fibers: Physiological Background and Possible Clinical Implications in Patients With Vertebrobasilar Stroke.Frontiers in neurology · 2021Review
- A Pilot Study of Facial Nerve Stimulation on Cerebral Artery Vasospasm in Subarachnoid Hemorrhage Patients.IEEE journal of translational engineering in health and medicine · 2019Article
- Facial nerve stimulation in normal pigs and healthy human volunteers: transitional development of a medical device for the emergency treatment of ischemic stroke.Journal of translational medicine · 2018Article
- Radiological anatomy assessment of the fissura pterygomaxillaris for a surgical approach to ganglion pterygopalatinum.Journal of anatomy · 2017Article
- Review
- Electrical stimulation of cranial nerves in cognition and disease.Brain stimulationReview
- Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stimulation of the autonomic parasympathetic fibers of the facial nerve system (hereafter simply "facial nerve") rapidly dilates the cerebral arteries and increases cerebral blood flow whether that stimulation is delivered at the facial nerve trunk or at distal points such as the sphenopalatine ganglion. Facial nerve stimulation thus could be used as an emergency treatment of conditions of brain ischemia such as ischemic stroke. A rich history of scientific research has examined this property of the facial nerve, and various means of activating the facial nerve can be employed including noninvasive means. Herein, we review the anatomical and physiological research behind facial nerve stimulation and the facial nerve stimulation devices that are in development for the treatment of ischemic stroke.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.