ArticleACS central science2018
Expanding the Chemical Space of Biocompatible Fluorophores: Nanohoops in Cells.
Article in ACS central science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- The advent of molecular nanocarbon biology.Chemical science · 2026Review
- Cross-dehydrogenative coupling macrocyclization for the construction of donor-acceptor nanohoops.Chemical science · 2026Article
- Bridging [8]cyclo-Chemical science · 2026Article
- A Precisely Bromo-Functionalized [9]Cycloparaphenylene as a Platform for Late-Stage Multisite π-Extension Toward Chiral Nanohoops.Angewandte Chemie (International ed. in English) · 2026Article
- Crown ether-cycloparaphenylene hybrid multimacrocycles: insights into supramolecular gas sensing and biological potential.Chemical science · 2025Article
- Cycloparaazine, a full-azine carbon nanoring.Nature communications · 2025Article
- Acceptor engineering of quinone-based cycloparaphenylenes via post-synthesis for achieving white-light emission in single-molecule.Nature communications · 2025Article
- Theoretical and modelling investigation of pendant groups effect on quantum interference for single-molecule junctions.RSC advances · 2024Article
- Carbon Nanomaterial Fluorescent Probes and Their Biological Applications.Chemical reviews · 2024Review
- Carbon Nanohoops: Multiple Molecular Templates for Exploring Spectroscopic, Electronic, and Thermoelectric Properties.ACS omega · 2024Article
- Ruthenium-Cyclopentadienyl-Cycloparaphenylene Complexes: Sizable Multicharged Cations Exhibiting High DNA-Binding Affinity and Remarkable Cytotoxicity.Molecules (Basel, Switzerland) · 2024Article
- Alkali metals doped cycloparaphenylene nanohoops: Promising nonlinear optical materials with enhanced performance.Heliyon · 2023Article
- Modular synthesis, host-guest complexation and solvation-controlled relaxation of nanohoops with donor-acceptor structures.Chemical science · 2022Article
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- Functional group introduction and aromatic unit variation in a set of π-conjugated macrocycles: revealing the central role of local and global aromaticity.Organic chemistry frontiers : an international journal of organic chemistry · 2021Article
- Confined Spaces in [n]Cyclo-2,7-pyrenylenes.Angewandte Chemie (International ed. in English) · 2021Article
- Nanohoop Rotaxane Design to Enhance the Selectivity of Reaction-Based Probes: A Proof-of-Principle Study.Organic letters · 2021Article
- Nanoparticles based on the zwitterionic pillar[5]arene and AgBeilstein journal of nanotechnology · 2020Article
- Enhancement of Binding Affinity of Folate to Its Receptor by Peptide Conjugation.International journal of molecular sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The design and optimization of fluorescent molecules has driven the ability to interrogate complex biological events in real time. Notably, most advances in bioimaging fluorophores are based on optimization of core structures that have been known for over a century. Recently, new synthetic methods have resulted in an explosion of nonplanar conjugated macrocyclic molecules with unique optical properties yet to be harnessed in a biological context. Herein we report the synthesis of the first aqueous-soluble carbon nanohoop (i.e., a macrocyclic slice of a carbon nanotube prepared via organic synthesis) and demonstrate its bioimaging capabilities in live cells. Moreover, we illustrate that these scaffolds can be easily modified by well-established "click" chemistry to enable targeted live cell imaging. This work establishes the nanohoops as an exciting new class of macrocyclic fluorophores poised for further development as novel bioimaging tools.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.