Evidence map›Paper›PMID 30276173›Full record

ReviewJournal of exercise rehabilitation2018

Role of exercise in age-related sarcopenia.

Su-Zi Yoo, Mi-Hyun No, Jun-Won Heo, Dong-Ho Park, Ju-Hee Kang, So Hun Kim, Hyo-Bum Kwak

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of exercise rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 118 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06637228 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Integrated Exercise on Sarcopenia, Depression Symptoms, and Quality of Life of Community-Dwelling Older Adults With Dementia

TypeinterventionalSponsorChang Gung University of Science and TechnologyRan2023 to 2024Enrolled80ConditionsDementia, Depressive Symptoms, Quality of Life (QOL), Sarcopenia in ElderlyArmsMove Your Hands, Feet, and Brain: Integrated Exercise Intervention Based on Taipei City Elderly Physical Activity Guidelines
NCT07253714 nacompletednot on this mapstarted 2024, after this paper: background citation

The effect of proprioceptive exercise training on cervical proprioception, kinesiophobia, and pain catastrophizing levels in sarcopenic geriatric individuals residing in nursing homes

TypeinterventionalSponsorAtılım UniversityRan2024 to 2024Enrolled31ConditionsSarcopenia in ElderlyArmsClassic exercises, Proprioceptive exercise training
3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Circulating Mediators of Apoptosis and Inflammation in Aging; Physical Exercise Intervention.International journal of environmental research and public health · 2021
    Trial
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  20. Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Su-Zi YooDepartment of Kinesiology, Inha University, Incheon, Korea.
Mi-Hyun NoDepartment of Kinesiology, Inha University, Incheon, Korea.
Jun-Won HeoDepartment of Kinesiology, Inha University, Incheon, Korea.
Dong-Ho ParkDepartment of Kinesiology, Inha University, Incheon, Korea.
Ju-Hee KangDepartment of Pharmacology and Medicinal Toxicology Research Center, Inha University School of Medicine, Incheon, Korea.
So Hun KimDepartment of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
Hyo-Bum KwakDepartment of Kinesiology, Inha University, Incheon, Korea.ORCID https://orcid.org/0000-0003-0451-4554

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcopenia is an age-associated decline of skeletal muscle mass and function and is known to lead to frailty, cachexia, osteoporosis, metabolic syndromes, and death. Notwithstanding the increasing incidence of sarcopenia, the molecular and cellular mechanisms driving age-related sarcopenia are not completely understood. This article reviews current definitions of sarcopenia, its potential mechanisms, and effects of exercise on sarcopenia. The pathogenesis of age-related sarcopenia is multifactorial and includes myostatin, inflammatory cytokines, and mitochondria-derived problems. Especially, age-induced mitochondrial dysfunction triggers the production of reactive oxygen species (ROS) by mitochondria, impedes mitochondrial dynamics, interrupts mitophagy, and leads to mitochondria-mediated apoptosis. Aerobic exercise provides at least a partial solution to sarcopenia as it ameliorates mitochondria-derived problems, and resistance exercise strengthens muscle mass and function. Furthermore, combinations of these exercise types provide the benefits of both. Collectively, this review summarizes potential mechanisms of age-related sarcopenia and emphasizes the use of exercise as a therapeutic strategy, suggesting that combined exercise provides the most beneficial means of combating age-related sarcopenia.

Indexed as

AgingExerciseMitochondriaSarcopeniaSkeletal muscle

Identifiers

PMID30276173
PMCPMC6165967

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.