ArticleLight, science & applications2018
Optical conductivity-based ultrasensitive mid-infrared biosensing on a hybrid metasurface.
Article in Light, science & applications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed.
- Flatland Metasurfaces for Optical Gas Sensing.Sensors (Basel, Switzerland) · 2026Review
- Plasmonics Meets Metasurfaces: A Vision for Next Generation Planar Optical Systems.Micromachines · 2026Review
- Unlocking the Translational Potential of Nanophotonic Biosensors: Perspectives on Application-Guided Design.ACS photonics · 2025Review
- Enhanced Spectral Tunability by Sub-10 nm Nanogaps in Graphene-Metal Hybrid Metasurfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Quantum vibropolaritonic sensing.Science advances · 2025Article
- Biofunctionalization of chalcogenide glass fiber to enhance real time and label free detection by mid infrared spectroscopy.Scientific reports · 2025Article
- Graphene-based metasurface: dynamic optical control in ultrathin flat optics.Nanophotonics (Berlin, Germany) · 2025Review
- Metasurface-enhanced biomedical spectroscopy.Nanophotonics (Berlin, Germany) · 2025Review
- Ultrasensitive metasurface sensor based on quasi-bound states in the continuum.Nanophotonics (Berlin, Germany) · 2025Article
- Advances in Nanoengineered Terahertz Technology: Generation, Modulation, and Bio-Applications.Research (Washington, D.C.) · 2025Review
- Protocol for Therapeutic Drug Monitoring Within the Clinical Range Using Mid-infrared Spectroscopy.Analytical chemistry · 2024Article
- Article
- Non-invasive measurements of blood glucose levels by time-gating mid-infrared optoacoustic signals.Nature metabolism · 2024Article
- Complex-frequency waves: beat loss and win sensitivity.Light, science & applications · 2024Article
- Dynamic construction of refractive index-dependent vibrations using surface plasmon-phonon polaritons.Nature communications · 2023Article
- Research Progress in Surface-Enhanced Infrared Absorption Spectroscopy: From Performance Optimization, Sensing Applications, to System Integration.Nanomaterials (Basel, Switzerland) · 2023Review
- A review of Optical Point-of-Care devices to Estimate the Technology Transfer of These Cutting-Edge Technologies.Biosensors · 2022Review
- Calibration-free, high-precision, and robust terahertz ultrafast metasurfaces for monitoring gastric cancers.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Terahertz Vibrational Fingerprints Detection of Molecules with Particularly Designed Graphene Biosensors.Nanomaterials (Basel, Switzerland) · 2022Article
- Wavelength-multiplexed hook nanoantennas for machine learning enabled mid-infrared spectroscopy.Nature communications · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical devices are highly attractive for biosensing as they can not only enable quantitative measurements of analytes but also provide information on molecular structures. Unfortunately, typical refractive index-based optical sensors do not have sufficient sensitivity to probe the binding of low-molecular-weight analytes. Non-optical devices such as field-effect transistors can be more sensitive but do not offer some of the significant features of optical devices, particularly molecular fingerprinting. We present optical conductivity-based mid-infrared (mid-IR) biosensors that allow for sensitive and quantitative measurements of low-molecular-weight analytes as well as the enhancement of spectral fingerprints. The sensors employ a hybrid metasurface consisting of monolayer graphene and metallic nano-antennas and combine individual advantages of plasmonic, electronic and spectroscopic approaches. First, the hybrid metasurface sensors can optically detect target molecule-induced carrier doping to graphene, allowing highly sensitive detection of low-molecular-weight analytes despite their small sizes. Second, the resonance shifts caused by changes in graphene optical conductivity is a well-defined function of graphene carrier density, thereby allowing for quantification of the binding of molecules. Third, the sensor performance is highly stable and consistent thanks to its insensitivity to graphene carrier mobility degradation. Finally, the sensors can also act as substrates for surface-enhanced infrared spectroscopy. We demonstrated the measurement of monolayers of sub-nanometer-sized molecules or particles and affinity binding-based quantitative detection of glucose down to 200 pM (36 pg/mL). We also demonstrated enhanced fingerprinting of minute quantities of glucose and polymer molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.