Evidence map›Paper›PMID 30275938›Full record

ReviewJournal of extracellular vesicles2018

Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy.

Jennifer Phan, Priyadarsini Kumar, Dake Hao, Kewa Gao, Diana Farmer, Aijun Wang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of extracellular vesicles, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 5 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 5 syntheses or guidelines pooled it, 345 citations in OpenAlex.

  1. Pooled it
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  6. Extracellular Vesicles and Their Role in Osteogenesis.Bioengineering (Basel, Switzerland) · 2026
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  19. Effects of hypoxic and photobiomodulation preconditioning on mesenchymal stem cell-derived exosomes: an in vitro study with an osteogenic potential approach.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  20. Article

141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jennifer PhanSurgical Bioengineering Laboratory, Department of Surgery, University of California, Davis School of Medicine, Sacramento, CA, USA.ORCID 0000-0002-0163-8562
Priyadarsini KumarSurgical Bioengineering Laboratory, Department of Surgery, University of California, Davis School of Medicine, Sacramento, CA, USA.
Dake HaoSurgical Bioengineering Laboratory, Department of Surgery, University of California, Davis School of Medicine, Sacramento, CA, USA.
Kewa GaoSurgical Bioengineering Laboratory, Department of Surgery, University of California, Davis School of Medicine, Sacramento, CA, USA.
Diana FarmerSurgical Bioengineering Laboratory, Department of Surgery, University of California, Davis School of Medicine, Sacramento, CA, USA.ORCID 0000-0002-3530-5993
Aijun WangSurgical Bioengineering Laboratory, Department of Surgery, University of California, Davis School of Medicine, Sacramento, CA, USA.ORCID 0000-0002-2985-3627
Shriners Hospitals for Children - Erie · USCalifornia State University, Sacramento · USCentral South University · CN

Funding

Fetal Tissue Engineering to Treat Spina Bifida Before BirthR01NS100761 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WANG, AIJUN · 2017 to 2021
$1.7M
Guinea pigs as a model of in utero stem cell therapy for spina bifidaR03HD091601 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WANG, AIJUN · 2017 to 2018
$157k
NICHD NIH HHS R03 HD091601NINDS NIH HHS R01 NS100761
6 · The paper itself

Abstract

Through traditional medicine, there were diseases and disorders that previously remained untreated or were simply thought to be incurable. Since the discovery of mesenchymal stem cells (MSCs), there has been a flurry of research to develop MSC-based therapy for diseases and disorders. It is now well-known that MSCs do not typically engraft after transplantation and exhibit their therapeutic effect via a paracrine mechanism. In addition to secretory proteins, MSCs also produce extracellular vesicles (EVs), membrane-bound nanovesicles containing proteins, DNA and RNA. The secreted vesicles then interact with target cells and deliver their contents, imparting their ultimate therapeutic effect. Unlike the widely studied cancer cells, the yield of MSC-exosomes is a limiting factor for large-scale production for cell-free therapies. Here we summarise potential approaches to increase the yield of such vesicles while maintaining or enhancing their efficacy by engineering the extracellular environment and intracellular components of MSCs.

Indexed as

extracellular vesiclesMesenchymal stem cells

Identifiers

PMID30275938
PMCPMC6161586
OpenAlexW2894350370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.