ReviewAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2018
Non-IgE-mediated food hypersensitivity.
Review in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 87 citations in OpenAlex.
- Feeding characteristics in young children with IgE-mediated food allergies: A cross-sectional observational study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Observational
- Assessment of Allergenic Potential for Cross-Reactivity of Olive (Food science & nutrition · 2026Article
- Article
- Non-immunoglobulin E-mediated gastrointestinal food allergies in children with Down syndrome: An epidemiological study.The World Allergy Organization journal · 2025Article
- The Immunological Mechanisms Involved in the Pathophysiology of Allergic Proctocolitis.Children (Basel, Switzerland) · 2025Article
- Food Hypersensitivity: Distinguishing Allergy from Intolerance, Main Characteristics, and Symptoms-A Narrative Review.Nutrients · 2025Review
- Non-immunoglobulin E-mediated food allergy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024Review
- Article
- Wheat-Related Disorders in Children: A 360-Degree View.Children (Basel, Switzerland) · 2024Review
- Food Intolerances, Food Allergies and IBS: Lights and Shadows.Nutrients · 2024Review
- Food protein-induced enteropathy: a revision for the clinician.Frontiers in pediatrics · 2024Review
- Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice.Nature microbiology · 2023Article
- Allergic Proctocolitis: Literature Review and Proposal of a Diagnostic-Therapeutic Algorithm.Life (Basel, Switzerland) · 2023Review
- Article
- Food protein-induced enterocolitis syndrome in response to salmon roe and trout roe.The journal of allergy and clinical immunology. Global · 2023Article
- Perspectives on Non-IgE-Mediated Gastrointestinal Food Allergy in Pediatrics: A Review of Current Evidence and Guidelines.Journal of asthma and allergy · 2023Review
- Clinical Manifestations of Pediatric Food Allergy: a Contemporary Review.Clinical reviews in allergy & immunology · 2022Review
- Prevalence of Food Allergy and Common Food Allergen Among Saudi Adults in Makkah Region, Saudi Arabia.Journal of asthma and allergy · 2022Article
- The challenging diagnosis of food protein-induced enterocolitis syndrome: A case report series.Frontiers in pediatrics · 2022Article
- Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches.Foods (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-immunoglobulin E (IgE)-mediated food hypersensitivity includes a spectrum of disorders that predominantly affect the gastrointestinal tract. This review will focus on the following more common non-IgE-mediated food hypersensitivity syndromes: food protein-induced enterocolitis syndrome (FPIES), allergic proctocolitis (AP), food protein-induced enteropathy (FPE) and celiac disease. FPIES, AP and FPE typically present in infancy and are most commonly triggered by cow's milk protein or soy. The usual presenting features are profuse emesis and dehydration in FPIES; blood-streaked and mucousy stools in AP; and protracted diarrhea with malabsorption in FPE. Since there are no confirmatory noninvasive diagnostic tests for most of these disorders, the diagnosis is based on a convincing history and resolution of symptoms with food avoidance. The mainstay of management for FPIES, AP and FPE is avoidance of the suspected inciting food, with periodic oral food challenges to assess for resolution, which generally occurs in the first few years of life. Celiac disease is an immune-mediated injury caused by the ingestion of gluten that leads to villous atrophy in the small intestine in genetically susceptible individuals. Serologic tests and small intestinal biopsy are required to confirm the diagnosis of celiac disease, and management requires life-long adherence to a strict gluten-free diet.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.