Evidence map›Paper›PMID 30275816›Full record

ArticleFrontiers in neural circuits2018

GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing.

Steffen Wolter, Dorit Möhrle, Hannes Schmidt, Sylvia Pfeiffer, Dennis Zelle, Philipp Eckert, Michael Krämer, Robert Feil, Peter K D Pilz, Marlies Knipper and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neural circuits, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  2. ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Steffen WolterDepartment of Otolaryngology, Head and Neck Surgery, Molecular Physiology of Hearing, Tübingen Hearing Research Centre, University of Tübingen, Tübingen, Germany.
Dorit MöhrleDepartment of Otolaryngology, Head and Neck Surgery, Molecular Physiology of Hearing, Tübingen Hearing Research Centre, University of Tübingen, Tübingen, Germany.
Hannes SchmidtInterfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Sylvia PfeifferDepartment of Animal Physiology, University of Tübingen, Tübingen, Germany.
Dennis ZelleDepartment of Otolaryngology, Head and Neck Surgery, Physiological Acoustics and Communication, Tübingen Hearing Research Centre, University of Tübingen, Tübingen, Germany.
Philipp EckertDepartment of Otolaryngology, Head and Neck Surgery, Molecular Physiology of Hearing, Tübingen Hearing Research Centre, University of Tübingen, Tübingen, Germany.
Michael KrämerInterfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Robert FeilInterfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
Peter K D PilzDepartment of Animal Physiology, University of Tübingen, Tübingen, Germany.
Marlies KnipperDepartment of Otolaryngology, Head and Neck Surgery, Molecular Physiology of Hearing, Tübingen Hearing Research Centre, University of Tübingen, Tübingen, Germany.
Lukas RüttigerDepartment of Otolaryngology, Head and Neck Surgery, Molecular Physiology of Hearing, Tübingen Hearing Research Centre, University of Tübingen, Tübingen, Germany.
University of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sensory axon T-like branching (bifurcation) in neurons from dorsal root ganglia and cranial sensory ganglia depends on the molecular signaling cascade involving the secreted factor C-type natriuretic peptide, the natriuretic peptide receptor guanylyl cyclase B (GC-B; also known as Npr2) and cGMP-dependent protein kinase I (cGKI, also known as PKGI). The bifurcation of cranial nerves is suggested to be important for information processing by second-order neurons in the hindbrain or spinal cord. Indeed, mice with a spontaneous GC-B loss of function mutation (

Indexed as

AnimalsAtrial Natriuretic Factor Receptor BAuditory PerceptionAuditory ThresholdAxonsCochlear NerveCranial NervesEvoked Potentials, AuditoryFemaleMaleMiceMice, Inbred C57BLMice, KnockoutPrepulse InhibitionReceptors, Atrial Natriuretic FactorReflex, StartleAtrial Natriuretic Factor Receptor BReceptors, Atrial Natriuretic FactorABRacoustic startlecochlear efferentsdevelopmentDPOAENpr2olivocochlear systemPPI

Identifiers

PMID30275816
PMCPMC6152484
OpenAlexW2889071892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.