ArticleInternational journal of medical sciences2018
GABAergic Alterations in the Rat Testis after Methamphetamine Exposure.
Article in International journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Mechanisms underlying methamphetamine-induced disruption of testicular integrity.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Microbiota contribute to regulation of the gut-testis axis in seasonal spermatogenesis.The ISME journal · 2025Article
- Toxic Effects of Methamphetamine on Reproductive Systems, Embryo Development, and Newborns: An Evidence-based Review.Current medicinal chemistry · 2025Review
- An overview of the methamphetamine effect on male sexual behavior and reproductive system.Physiological research · 2023Review
- Adverse effects of methamphetamine on vital organs of male rats: Histopathological and immunohistochemical investigations.Iranian journal of basic medical sciences · 2023Article
- Recreational Drug Misuse and Its Potential Contribution to Male Fertility Levels' Decline: A Narrative Review.Brain sciences · 2022Review
- Methamphetamine Downregulates the Sperm-Specific Calcium Channels Involved in Sperm Motility in Rats.ACS omega · 2022Article
- High mRNA expression of GABA receptors in human sperm with oligoasthenoteratozoospermia and teratozoospermia and its association with sperm parameters and intracytoplasmic sperm injection outcomes.Clinical and experimental reproductive medicine · 2021Article
- Reduced Glycolysis Contributed to Inhibition of Testis Spermatogenesis in Rats After Chronic Methamphetamine Exposure.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Substance Abuse and Male Hypogonadism.Journal of clinical medicine · 2019Review
- Testicular expression of long non-coding RNAs is affected by curative GnRHa treatment of cryptorchidism.Basic and clinical andrology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gamma-aminobutyric acid (GABA), GABA-A receptors and GABA transporter 1 (GAT1) were reported to be involved in the proliferation of Leydig cells, testosterone production and spermatogenesis. Since methamphetamine (METH) has been reported to have adverse effects on testis and its functions, the aim of this study was therefore to determine the changes of GABAergic activity in testis after METH exposure. Male Sprague-Dawley rats were divided into control, acute binge (AB-METH), escalating dose (ED METH) and escalating dose-binge (ED-binge METH) groups. After sacrifice, rat testes were removed and used to estimate GABA concentration and the expression of GABA-A receptor, GAD1, GAD2 and GAT1 genes by using HPLC and RT-PCR, respectively. The GABA concentration was significantly increased in all METH-administrated groups. In addition, significant increases of GABA-A α1 receptor and GAD1 genes expression were found in the ED-binge METH group. Gene expressions of GAT1 were numerically decreased in all METH-administrated rats and reached significant in the ED METH group. These results indicated a compensatory upregulation of GABA production and its functions in testis after METH exposure. Thus, these changes might represent a homeostatic response of GABAergic to the adverse effects of METH.
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