ArticleNeuropsychiatric disease and treatment2018
Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study.
Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Amblyopia: progress and promise of functional magnetic resonance imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Pooled it
- Altered regional homogeneity in patients with diabetic vitreous hemorrhage.World journal of diabetes · 2020Trial
- Altered Spontaneous Brain Activity in Adolescents and Adults with Comitant Strabismus and Strabismic Amblyopia.Ophthalmology science · 2026Article
- Abnormal white matter in the visual pathways of strabismus with and without amblyopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Neurovascular Coupling Disruption and Glymphatic Dysfunction Are Associated With Visual Impairment in Pediatric Monocular Anisometropic Amblyopia.Investigative ophthalmology & visual science · 2026Article
- Altered spontaneous brain activity in children with deprivation amblyopia: a resting-state functional magnetic resonance imaging study.European journal of medical research · 2025Article
- Dynamic changes of spontaneous brain activity in patients after LASIK: a resting-state fMRI study.International journal of ophthalmology · 2025Article
- Altered functional connectivity of the default mode network in non-arteritic anterior ischaemic optic neuropathy.Brain communications · 2024Article
- Functional connectivity of paired default mode network subregions in patients with eye trauma.International journal of ophthalmology · 2024Article
- Abnormal topological organization of functional brain networks in the patients with anterior segment ischemic optic neuropathy.Frontiers in neuroscience · 2024Article
- Update on central factors in myopia development beyond intraocular mechanisms.Frontiers in neurology · 2024Review
- Altered spontaneous brain activity patterns in hypertensive retinopathy using fractional amplitude of low-frequency fluctuations: a functional magnetic resonance imaging study.International journal of ophthalmology · 2024Article
- Structural and functional alterations in the brains of patients with anisometropic and strabismic amblyopia: a systematic review of magnetic resonance imaging studies.Neural regeneration research · 2023Article
- A multimodal MRI study of functional and structural changes in concomitant exotropia.Experimental and therapeutic medicine · 2023Article
- Alterations of spontaneous brain activity in type 2 diabetes mellitus without mild cognitive impairment: a resting-state functional magnetic resonance study.Frontiers in human neuroscience · 2023Article
- Amplitude of Low-Frequency Fluctuation to Determine Disturbed Spontaneous Brain-Activity Pattern in Patients with Diabetic Optic Neuropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Differences in the Visual Performances of Patients with Strabismus, Amblyopia, and Healthy Controls.Bioengineering (Basel, Switzerland) · 2022Article
- [Abnormal spontaneous brain functional activity in adult patients with amblyopia: a resting-state functional magnetic resonance imaging study].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Article
- Investigation of changes in the activity and function of dry eye-associated brain regions using the amplitude of low-frequency fluctuations method.Bioscience reports · 2022Article
- Gray matter volume alterations in patients with strabismus and amblyopia: voxel-based morphometry study.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrevious studies have demonstrated that strabismus or amblyopia can result in markedly brain function and anatomical alterations. However, the differences in spontaneous brain activities of strabismus with amblyopia (SA) patients still remain unclear. This current study intended to use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the intrinsic brain activity changes in SA subjects. PATIENTS AND
methodsA total of 16 patients with SA (6 males and 10 females) and 16 healthy controls (HCs; 6 males and 10 females) similarly matched in age, gender, and education status were recruited and examined with the resting-state functional MRI. The spontaneous brain activity changes were investigated using the ALFF technique. The receiver operating characteristic curve was performed to classify the mean ALFF signal values of the SA patients from HCs. The correlations between the ALFF values of distinct brain regions and the clinical manifestations in SA patients were evaluated in terms of the Pearson's correlation analysis.
resultsCompared with HCs, SA patients had significantly decreased ALFF in the left cerebellum posterior lobe, left middle frontal gyrus, and bilateral thalamus. In contrast, SA patients showed increased ALFF values in the right superior frontal gyrus, right precuneus, left cuneus, and bilateral precentral gyrus. Nonetheless, there was no linear correlation between the mean ALFF values in brain regions and clinical features.
conclusionDiverse brain regions including vision-related and motion-related areas exhibited aberrant intrinsic brain activity patterns, which imply the neuropathologic mechanisms of oculomotor disorder and vision deficit in the SA patients.
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