Evidence map›Paper›PMID 30275632›Full record

ArticleJournal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)2018

Potential of Aqueous Two-Phase Systems for the Separation of Levodopa from Similar Biomolecules.

Rita de Cássia S Sousa, Catarina M S S Neves, Matheus M Pereira, Mara G Freire, João A P Coutinho

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 12 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Rita de Cássia S SousaCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Catarina M S S NevesCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Matheus M PereiraCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Mara G FreireCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
João A P CoutinhoCICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
University of Aveiro · PTUniversidade Federal de Viçosa · BR

Funding

European Research Council 337753
6 · The paper itself

Abstract

backgroundLevodopa is a precursor of several neurotransmitters, such as dopamine, and is used in the treatment of the Parkinson's disease. In this work, an alternative strategy was studied to separate levodopa from similar biomolecules using aqueous two-phase systems (ATPS).

resultsTernary ATPS composed of polyethylene glycol (PEG) 400 or ionic liquids (ILs), citrate buffer (K

conclusionThe results obtained indicated that PEG-based ATPS were the most effective to separate levodopa from L-phenylalanine while the separation from the other biomolecules was better using IL-based ATPS, in particular those based on [P

Indexed as

amino acidsaqueous two-phase systemsextractionionic liquidslevodopaseparation

Identifiers

PMID30275632
PMCPMC6161814
OpenAlexW2779019541

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.