ArticleNature methods2018
Fast and accurate data collection for macromolecular crystallography using the JUNGFRAU detector.
Article in Nature methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 74 citations in OpenAlex.
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- The structure of His15 acetamide-modified hen egg-white lysozyme: a nice surprise from an old friend.Acta crystallographica. Section F, Structural biology communications · 2025Article
- Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron.Communications chemistry · 2025Article
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- AI-NERD: Elucidation of relaxation dynamics beyond equilibrium through AI-informed X-ray photon correlation spectroscopy.Nature communications · 2024Article
- Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography.Nature chemistry · 2024Article
- The time revolution in macromolecular crystallography.Structural dynamics (Melville, N.Y.) · 2024Article
- Deep residual networks for crystallography trained on synthetic data.Acta crystallographica. Section D, Structural biology · 2024Article
- Engineering Supramolecular Hybrid Architectures with Directional Organofluorine Bonds.Small science · 2024Article
- Electron counting with direct electron detectors in MicroED.Structure (London, England : 1993) · 2023Article
- Kilohertz serial crystallography with the JUNGFRAU detector at a fourth-generation synchrotron source.IUCrJ · 2023Article
- A versatile approach to high-density microcrystals in lipidic cubic phase for room-temperature serial crystallography.Journal of applied crystallography · 2023Article
- XFEL Microcrystallography of Self-Assembling SilverJournal of the American Chemical Society · 2023Article
- Bragg coherent diffraction imaging with the CITIUS charge-integrating detector.Journal of applied crystallography · 2023Article
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17 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The accuracy of X-ray diffraction data is directly related to how the X-ray detector records photons. Here we describe the application of a direct-detection charge-integrating pixel-array detector (JUNGFRAU) in macromolecular crystallography (MX). JUNGFRAU features a uniform response on the subpixel level, linear behavior toward high photon rates, and low-noise performance across the whole dynamic range. We demonstrate that these features allow accurate MX data to be recorded at unprecedented speed. We also demonstrate improvements over previous-generation detectors in terms of data quality, using native single-wavelength anomalous diffraction (SAD) phasing, for thaumatin, lysozyme, and aminopeptidase N. Our results suggest that the JUNGFRAU detector will substantially improve the performance of synchrotron MX beamlines and equip them for future synchrotron light sources.
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