ArticleNature methods2018
All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
Article in Nature methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Highly attenuated dendritic propagation of isolated synaptic potentials in vivo.Science advances · 2026Article
- Noise Sources and Strategies for Signal Quality Improvement in Biological Imaging: A Review Focused on Calcium and Cell Membrane Voltage Imaging.Biosensors · 2026Review
- Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the awake and anesthetized mouse brain.Cell reports · 2024Article
- Robust self-supervised denoising of voltage imaging data using CellMincer.bioRxiv : the preprint server for biology · 2024Article
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- Voltage Imaging with Engineered Proton-Pumping Rhodopsins: Insights from the Proton Transfer Pathway.ACS physical chemistry Au · 2023Review
- A positively tuned voltage indicator for extended electrical recordings in the brain.Nature methods · 2023Article
- Article
- Reduced biophotonic activities and spectral blueshift in Alzheimer's disease and vascular dementia models with cognitive impairment.Frontiers in aging neuroscience · 2023Article
- A Simple CaMethods in molecular biology (Clifton, N.J.) · 2023Article
- Multiregion neuronal activity: the forest and the trees.Nature reviews. Neuroscience · 2022Review
- Optical Electrophysiology: Toward the Goal of Label-Free Voltage Imaging.Journal of the American Chemical Society · 2021Article
- A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons.Nature chemistry · 2021Article
- A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics.Trends in neurosciences · 2021Review
- A simple CaJournal of neuroscience methods · 2021Article
- Imaging Voltage with Microbial Rhodopsins.Frontiers in molecular biosciences · 2021Review
- Aberrant Auditory Steady-State Response of Awake Mice After Single Application of the NMDA Receptor Antagonist MK-801 Into the Medial Geniculate Body.The international journal of neuropsychopharmacology · 2020Article
- BATTLE: Genetically Engineered Strategies for Split-Tunable Allocation of Multiple Transgenes in the Nervous System.iScience · 2020Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Optical assays of synaptic strength could facilitate studies of neuronal transmission and its dysregulation in disease. Here we introduce a genetic toolbox for all-optical interrogation of synaptic electrophysiology (synOptopatch) via mutually exclusive expression of a channelrhodopsin actuator and an archaerhodopsin-derived voltage indicator. Optically induced activity in the channelrhodopsin-expressing neurons generated excitatory and inhibitory postsynaptic potentials that we optically resolved in reporter-expressing neurons. We further developed a yellow spine-targeted Ca
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