Evidence map›Paper›PMID 30275573›Full record

SynthesisNature methods2018

Qiita: rapid, web-enabled microbiome meta-analysis.

Antonio Gonzalez, Jose A Navas-Molina, Tomasz Kosciolek, Daniel McDonald, Yoshiki Vázquez-Baeza, Gail Ackermann, Jeff DeReus, Stefan Janssen, Austin D Swafford, Stephanie B Orchanian and 13 more

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature methods, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05185713 (The Mechanism of Vaginal Flora and Its Metabolites in the Pathogenesis of Cervical Cancer), which is not on this map. Cited by 430 papers.

0numbers the graph read from it
0cells of the map it votes in
430citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05185713 unknown statusnot on this mapstarted 2022, after this paper: background citation

The Mechanism of Vaginal Flora and Its Metabolites in the Pathogenesis of Cervical Cancer

Typeobservational_patient_registrySponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityRan2022 to 2023Enrolled300ConditionsCervical CancerArmsThis project is a clinical observational study. No additional medication or surgical interventions are performed on the subjects.
3 · Its place in the literature

Who cites it

430 citing papers in PubMed.

  1. Trial
  2. Article
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  4. Article
  5. Comparative genomic analysis ofMicrobiology spectrum · 2026
    Article
  6. Article
  7. Review
  8. Behavioral and Microbial Profiling of the Bethylid WaspBiological control : theory and applications in pest management · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Observational

370 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Antonio GonzalezDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Jose A Navas-MolinaDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4595-920X
Tomasz KosciolekDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Daniel McDonaldDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Yoshiki Vázquez-BaezaDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Gail AckermannDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Jeff DeReusDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Stefan JanssenDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Austin D SwaffordCenter for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA.
Stephanie B OrchanianCenter for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA.
Jon G SandersDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Joshua ShorensteinDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Hannes HolsteDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-7739-6590
Semar PetrusDepartment of Biology, University of California, San Diego, La Jolla, CA, USA.
Adam Robbins-PiankaDepartment of Computer Science, University of Colorado, Boulder, Boulder, CO, USA.
Colin J BrislawnEarth & Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA, USA.
Mingxun WangCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
Jai Ram RideoutPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.ORCID http://orcid.org/0000-0003-2587-1454
Evan BolyenPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
Matthew DillonPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
J Gregory CaporasoPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.ORCID http://orcid.org/0000-0002-8865-1670
Pieter C DorresteinDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3003-1030
Rob KnightDepartment of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA. robknight@ucsd.edu.ORCID http://orcid.org/0000-0002-0975-9019

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
Trace the flow of genes in the gut microbiome of obese and lean twin pairsP01DK078669 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I · 2007 to 2018
$16.0M
Epidemiology of the gut microbiome, prediabetes and diabetes in LatinosR01MD011389 · NIMHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BURK, ROBERT D, KAPLAN, ROBERT C · 2016 to 2020
$4.3M
Integrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolitesR01HL140976 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KAPLAN, ROBERT C, KNIGHT, ROB · 2018 to 2021
$3.3M
New Tools for Understanding the Composition and Dynamics of Microbial CommunitiesR01HG004872 · NHGRI · UNIVERSITY OF COLORADO · PI KNIGHT, ROB · 2008 to 2012
$1.8M
NHGRI NIH HHS R01 HG004872NHLBI NIH HHS R01 HL140976NIDDK NIH HHS P01 DK078669NIMHD NIH HHS R01 MD011389NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

Multi-omic insights into microbiome function and composition typically advance one study at a time. However, in order for relationships across studies to be fully understood, data must be aggregated into meta-analyses. This makes it possible to generate new hypotheses by finding features that are reproducible across biospecimens and data layers. Qiita dramatically accelerates such integration tasks in a web-based microbiome-comparison platform, which we demonstrate with Human Microbiome Project and Integrative Human Microbiome Project (iHMP) data.

Indexed as

InternetMetagenomicsMicrobiotaSoftwareComputational BiologyHumansUser-Computer Interface

Identifiers

PMID30275573
PMCPMC6235622

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.