Evidence map›Paper›PMID 30275541›Full record

ArticleNature communications2018

LISA improves statistical analysis for fMRI.

Gabriele Lohmann, Johannes Stelzer, Eric Lacosse, Vinod J Kumar, Karsten Mueller, Esther Kuehn, Wolfgang Grodd, Klaus Scheffler

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  17. Cortical Surface-Informed Volumetric Spatial Smoothing of fMRI Data via Graph Signal Processing.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabriele LohmannDepartment of Biomedical Magnetic Resonance Imaging, University Hospital Tübingen, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany. gabriele.lohmann@tuebingen.mpg.de.ORCID http://orcid.org/0000-0002-5922-9016
Johannes StelzerDepartment of Biomedical Magnetic Resonance Imaging, University Hospital Tübingen, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany.
Eric LacosseMagnetic Resonance Centre, Max-Planck-Institute for Biological Cybernetics, Max-Planck-Ring 11, 72076, Tübingen, Germany.
Vinod J KumarMagnetic Resonance Centre, Max-Planck-Institute for Biological Cybernetics, Max-Planck-Ring 11, 72076, Tübingen, Germany.
Karsten MuellerMethods & Development Group Nuclear Magnetic Resonance, Max-Planck-Institute for Human Cognitive and Brain Sciences, Stephanstrasse 1A, 04103, Leipzig, Germany.
Esther KuehnGerman Center for Neurodegenerative Diseases (DZNE), Leipziger Strasse 44, 39120, Magdeburg, Germany.
Wolfgang GroddMagnetic Resonance Centre, Max-Planck-Institute for Biological Cybernetics, Max-Planck-Ring 11, 72076, Tübingen, Germany.
Klaus SchefflerDepartment of Biomedical Magnetic Resonance Imaging, University Hospital Tübingen, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany.ORCID http://orcid.org/0000-0001-6316-8773

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

One of the principal goals in functional magnetic resonance imaging (fMRI) is the detection of local activation in the human brain. However, lack of statistical power and inflated false positive rates have recently been identified as major problems in this regard. Here, we propose a non-parametric and threshold-free framework called LISA to address this demand. It uses a non-linear filter for incorporating spatial context without sacrificing spatial precision. Multiple comparison correction is achieved by controlling the false discovery rate in the filtered maps. Compared to widely used other methods, it shows a boost in statistical power and allows to find small activation areas that have previously evaded detection. The spatial sensitivity of LISA makes it especially suitable for the analysis of high-resolution fMRI data acquired at ultrahigh field (≥7 Tesla).

Indexed as

AlgorithmsBrainBrain MappingComputer SimulationHumansMagnetic Resonance ImagingModels, StatisticalSensitivity and SpecificitySignal-To-Noise Ratio

Identifiers

PMID30275541
PMCPMC6167367

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.