Evidence map›Paper›PMID 30275537›Full record

ArticleCellular & molecular immunology2019

NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections.

Elias Abou-Samra, Zachary Hickey, Oscar A Aguilar, Michal Scur, Ahmad Bakur Mahmoud, Sergey Pyatibrat, Megan M Tu, Jeffrey Francispillai, Arthur Mortha, James R Carlyle and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. ILC3: a case of conflicted identity.Frontiers in immunology · 2023
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Elias Abou-SamraDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Zachary HickeyDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Oscar A AguilarDepartment of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Michal ScurDepartment of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS, B3H 4R2, Canada.
Ahmad Bakur MahmoudDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Sergey PyatibratDivision of Anatomical Pathology, Department of Pathology and Laboratory Medicine, The Ottawa Hospital, University of Ottawa, 501 Smyth Road, Ottawa, ON, K1H 8L6, Canada.
Megan M TuDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Jeffrey FrancispillaiDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada.
Arthur MorthaDepartment of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
James R CarlyleDepartment of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Mir Munir A RahimDepartment of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS, B3H 4R2, Canada. munirrahimm@dal.ca.
Andrew P MakrigiannisDepartment of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS, B3H 4R2, Canada. amakrigiannis@dal.ca.
University of Ottawa · CADalhousie University · CACanada Research Chairs · CASunnybrook Health Science Centre · CAUniversity of Toronto · CA

Funding

CIHR 388337CIHR 86630
6 · The paper itself

Abstract

Helper-type innate lymphoid cells (ILC) play an important role in intestinal homeostasis. Members of the NKR-P1 gene family are expressed in various innate immune cells, including natural killer (NK) cells, and their cognate Clr ligand family members are expressed in various specialized tissues, including the intestinal epithelium, where they may play an important role in mucosal-associated innate immune responses. In this study, we show that the inhibitory NKR-P1B receptor, but not the Ly49 receptor, is expressed in gut-resident NK cells, ILC, and a subset of γδT cells in a tissue-specific manner. ILC3 cells constitute the predominant cell subset expressing NKR-P1B in the gut lamina propria. The known NKR-P1B ligand Clr-b is broadly expressed in gut-associated cells of hematopoietic origin. The genetic deletion of NKR-P1B results in a higher frequency and number of ILC3 and γδT cells in the gut lamina propria. However, the function of gut-resident ILC3, NK, and γδT cells in NKR-P1B-deficient mice is impaired during gastrointestinal tract infection by Citrobacter rodentium or Salmonella typhimurium, resulting in increased systemic bacterial dissemination in NKR-P1B-deficient mice. Our findings highlight the role of the NKR-P1B:Clr-b recognition system in the modulation of intestinal innate immune cell functions.

Indexed as

Immunity, InnateAnimalsCitrobacter rodentiumEnterobacteriaceae InfectionsIntestinal DiseasesIntestinal MucosaKiller Cells, NaturalMiceMice, KnockoutNK Cell Lectin-Like Receptor Subfamily BReceptors, Antigen, T-Cell, gamma-deltaSalmonella InfectionsSalmonella typhimuriumT-LymphocytesKlrb1b protein, mouseNK Cell Lectin-Like Receptor Subfamily BReceptors, Antigen, T-Cell, gamma-deltaGut-associated immune cellsInnate immunityInnate lymphoid cellsNatural killer cellsNKR-P1B receptor

Identifiers

PMID30275537
PMCPMC6828740
OpenAlexW2894468473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.