Evidence map›Paper›PMID 30275509›Full record

ArticleScientific reports2018

Calcium increases titin N2A binding to F-actin and regulated thin filaments.

Samrat Dutta, Christopher Tsiros, Sai Lavanyaa Sundar, Humra Athar, Jeffrey Moore, Brent Nelson, Matthew J Gage, Kiisa Nishikawa

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 103 citations in OpenAlex.

  1. Article
  2. Article
  3. How temperature tunes muscle mechanics during eccentric contractions.American journal of physiology. Cell physiology · 2026
    Article
  4. Article
  5. Article
  6. Titin's Intrinsically Disordered PEVK Domain Modulates Actin Polymerization.International journal of molecular sciences · 2025
    Article
  7. Consecutive SSCs increase the SSC effect in skinned rat muscle fibres.Pflugers Archiv : European journal of physiology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The distinctive mechanical and structural signatures of residual force enhancement in myofibers.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Evidence for multi-scale power amplification in skeletal muscle.The Journal of experimental biology · 2023
    Article
  19. Hyphal Growth inMicrobiology spectrum · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Samrat DuttaCenter for Bioengineering Innovation, Northern Arizona University, Flagstaff, AZ, 86011-4185, USA.
Christopher TsirosChemistry Department, University of Massachusetts at Lowell, Lowell, MA, 01854, USA.
Sai Lavanyaa SundarBiological Sciences Department, University of Massachusetts at Lowell, Lowell, MA, 01854, USA.
Humra AtharChemistry Department, University of Massachusetts at Lowell, Lowell, MA, 01854, USA.
Jeffrey MooreBiological Sciences Department, University of Massachusetts at Lowell, Lowell, MA, 01854, USA.
Brent NelsonMechanical Engineering Department, Northern Arizona University, Flagstaff, AZ, 86011-15600, USA.
Matthew J GageChemistry Department, University of Massachusetts at Lowell, Lowell, MA, 01854, USA.
Kiisa NishikawaCenter for Bioengineering Innovation, Northern Arizona University, Flagstaff, AZ, 86011-4185, USA. Kiisa.Nishikawa@nau.edu.
University of Massachusetts Lowell · USNorthern Arizona University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in titin are responsible for many cardiac and muscle diseases, yet the underlying mechanisms remain largely unexplained. Numerous studies have established roles for titin in muscle function, and Ca

Indexed as

ActinsCalciumConnectinProtein BindingActinsCalciumConnectin

Identifiers

PMID30275509
PMCPMC6167357
OpenAlexW2894229977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.