Evidence map›Paper›PMID 30275401›Full record

ArticleInternational journal of molecular sciences2018

aP2-Cre Mediated Ablation of GHS-R Attenuates Adiposity and Improves Insulin Sensitivity during Aging.

Ligen Lin, Jong Han Lee, Ruitao Wang, Ru Wang, David Sheikh-Hamad, Qun S Zang, Yuxiang Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Ligen LinChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. ligenl@umac.mo.ORCID 0000-0002-6799-5327
Jong Han LeeChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. jhleecw@gmail.com.
Ruitao WangInstitute of Critical Care Medicine, Heilongjiang Academy of Medical Science, Heilongjiang 150081, China. ruitaowang@126.com.
Ru WangKey Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, China. wangru0612@163.com.
David Sheikh-HamadDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. sheikh@bcm.edu.
Qun S ZangDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. qun.zang@utsouthwestern.edu.
Yuxiang SunChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. Yuxiang.Sun@tamu.edu.
Shanghai University of Sport · CNBaylor College of Medicine · USChildren's Nutrition Research Center at Baylor College of Medicine · USGachon University · KRThe University of Texas Southwestern Medical Center · USUniversity of Macau · MO

Funding

Pathological Responses to Mitochondrial ROS in Sepsis-Induced Cardiac DysfunctionR01GM111295 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI ZANG, QUN SOPHIA · 2014 to 2022
$2.7M
NIGMS NIH HHS R01 GM111295
6 · The paper itself

Abstract

Ghrelin via its receptor, the growth hormone secretagogue receptor (GHS-R), increases food intake and adiposity. The tissue-specific functions of GHS-R in peripheral tissues are mostly unknown. We previously reported that while GHS-R expression is very low in white and brown fat of young mice, expression increases during aging. To investigate whether GHS-R has cell-autonomous effects in adipose tissues, we generated

Indexed as

AdiposityGene DeletionInsulin ResistanceAdipose Tissue, BrownAdipose Tissue, WhiteAgingAnimalsCarbohydratesEatingEnergy MetabolismFatty Acid-Binding ProteinsGene Knockdown TechniquesGhrelinGlucose Tolerance TestGrowth HormoneIntegrasesCarbohydratesCre recombinaseFabp4 protein, mouseFatty Acid-Binding ProteinsGhrelinGrowth HormoneIntegrasesProteinsReceptors, Ghrelinadipose tissuesghrelinGHS-Rthermogenesistissue-specific knockdown miceUCP1

Identifiers

PMID30275401
PMCPMC6213105
OpenAlexW2892574787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.