ArticleJournal of neural engineering2019
Anodic stimulation misunderstood: preferential activation of fiber orientations with anodic waveforms in deep brain stimulation.
Article in Journal of neural engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Auricular Vagus Neuromodulation-A Systematic Review on Quality of Evidence and Clinical Effects.Frontiers in neuroscience · 2021Pooled it
- Probabilistic comparison of gray and white matter coverage between depth and surface intracranial electrodes in epilepsy.Scientific reports · 2021Trial
- Home Health Management of Parkinson Disease Deep Brain Stimulation: A Randomized Clinical Trial.JAMA neurology · 2021Trial
- Chronic alcohol-induced brain states limit propagation of direct cortical stimulation.Scientific reports · 2025Article
- Neural pathway activation in the subthalamic region depends on stimulation polarity.Brain communications · 2025Article
- Optimal interphase delay in biphasic current pulses facilitates neural circuit activation induced by microstimulation in the mouse visual cortex.Frontiers in neuroscience · 2025Article
- Activation metrics for structural connectivity recruitment in deep brain stimulation.Brain communications · 2025Article
- The interplay between pulse width and activation depth in TENS: a computational study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Understanding novel neuromodulation pathways in tDCS: brain stem recordings in rats during trigeminal nerve direct current stimulation.Translational psychiatry · 2024Article
- The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond.Frontiers in human neuroscience · 2024Review
- Myogenic and cortical evoked potentials vary as a function of stimulus pulse geometry delivered in the subthalamic nucleus of Parkinson's disease patients.Frontiers in neurology · 2023Article
- Patient-specific structural connectivity informs outcomes of responsive neurostimulation for temporal lobe epilepsy.Epilepsia · 2022Article
- Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation.Journal of neural engineering · 2022Article
- Patient-specific modeling of the volume of tissue activated (VTA) is associated with clinical outcome of DBS in patients with an obsessive-compulsive disorder.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
- In vivo restricted diffusion imaging (RDI) is sensitive to differences in axonal density in typical children and adults.Brain structure & function · 2021Article
- Basal Ganglia Pathways Associated With Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Therapies to Restore Consciousness in Patients with Severe Brain Injuries: A Gap Analysis and Future Directions.Neurocritical care · 2021Article
- Impact of brain shift on neural pathways in deep brain stimulation: a preliminary analysis via multi-physics finite element models.Journal of neural engineering · 2021Article
- Computational investigation of the impact of deep brain stimulation contact size and shape on neural selectivity.Journal of neural engineering · 2021Article
- Orientation-selective and directional deep brain stimulation in swine assessed by functional MRI at 3T.NeuroImage · 2021Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
objectiveDuring deep brain stimulation (DBS), it is well understood that extracellular cathodic stimulation can cause activation of passing axons. Activation can be predicted from the second derivative of the electric potential along an axon, which depends on axonal orientation with respect to the stimulation source. We hypothesize that fiber orientation influences activation thresholds and that fiber orientations can be selectively targeted with DBS waveforms. APPROACH: We used bioelectric field and multicompartment NEURON models to explore preferential activation based on fiber orientation during monopolar or bipolar stimulation. Preferential fiber orientation was extracted from the principal eigenvectors and eigenvalues of the Hessian matrix of the electric potential. We tested cathodic, anodic, and charge-balanced pulses to target neurons based on fiber orientation in general and clinical scenarios. MAIN
resultsAxons passing the DBS lead have positive second derivatives around a cathode, whereas orthogonal axons have positive second derivatives around an anode, as indicated by the Hessian. Multicompartment NEURON models confirm that passing fibers are activated by cathodic stimulation, and orthogonal fibers are activated by anodic stimulation. Additionally, orthogonal axons have lower thresholds compared to passing axons. In a clinical scenario, fiber pathways associated with therapeutic benefit can be targeted with anodic stimulation at 50% lower stimulation amplitudes. SIGNIFICANCE: Fiber orientations can be selectively targeted with simple changes to the stimulus waveform. Anodic stimulation preferentially activates orthogonal fibers, approaching or leaving the electrode, at lower thresholds for similar therapeutic benefit in DBS with decreased power consumption.
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