Evidence map›Paper›PMID 30275337›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Serotonin signaling regulates insulin-like peptides for growth, reproduction, and metabolism in the disease vector

Lin Ling, Alexander S Raikhel

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
  2. Article
  3. Lipids in Insect Reproduction: Where, How, and Why.Advances in experimental medicine and biology · 2026
    Review
  4. Genomic and insulin-mediated control of metabolic homeostasis by the mosquito ecdysone-induced gene E93.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
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  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. The auditory efferent system in mosquitoes.Frontiers in cell and developmental biology · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lin LingDepartment of Entomology, University of California, Riverside, CA 92521.
Alexander S RaikhelDepartment of Entomology, University of California, Riverside, CA 92521; alexander.raikhel@ucr.edu.
University of California, Riverside · US

Funding

MOLECULAR BASIS OF ECDYSTEROID ACTION IN THE MOSQUITOR01AI036959 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI RAIKHEL, ALEXANDER SIMEON, ROY, SOURAV · 1995 to 2022
$10.0M
NIAID NIH HHS R01 AI036959
6 · The paper itself

Abstract

Disease-transmitting female mosquitoes require a vertebrate blood meal to produce their eggs. An obligatory hematophagous lifestyle, rapid reproduction, and existence of a large number of transmittable diseases make mosquitoes the world's deadliest animals. Attaining optimal body size and nutritional status is critical for mosquitoes to become reproductively competent and effective disease vectors. We report that blood feeding boosts serotonin concentration and elevates the serotonin receptor Aa5HT2B (

Indexed as

ReproductionAedesAnimalsCRISPR-Cas SystemsFemaleInsect ProteinsInsulinMosquito VectorsPeptide FragmentsReceptors, SerotoninSerotoninSignal TransductionInsect ProteinsInsulinPeptide FragmentsReceptors, SerotoninSerotoninserotonin 5 receptorbody sizeCRISPR-Cas9insulinmetabolismserotonin receptor

Identifiers

PMID30275337
PMCPMC6196551
OpenAlexW2894032080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.