ArticleProceedings of the National Academy of Sciences of the United States of America2018
Coordination of cell migration mediated by site-dependent cell-cell contact.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A Microfabricated Branch Selection Platform for Quantitative Measurement of Leader-Follower Interaction Strength and Interaction Range in Collective Cell Migration.Micromachines · 2026Article
- Emergence of multiple collective motility modes in a physical model of cell chains.NPJ systems biology and applications · 2025Article
- Geometrical constraint change determines organized collective migration of follower cells.Scientific reports · 2025Article
- Insights into mechanisms of MALT1 allostery from NMR and AlphaFold dynamic analyses.Communications biology · 2024Article
- Dynamics of multicellular swirling on micropatterned substrates.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Limits on the accuracy of contact inhibition of locomotion.Physical review. E · 2024Article
- PIEZO1 regulates leader cell formation and cellular coordination during collective keratinocyte migration.PLoS computational biology · 2024Article
- The Role of Mechanotransduction in Contact Inhibition of Locomotion and Proliferation.International journal of molecular sciences · 2024Review
- Understanding How Cells Probe the World: A Preliminary Step towards Modeling Cell Behavior?International journal of molecular sciences · 2023Article
- Picking winners in cell-cell collisions: Wetting, speed, and contact.Physical review. E · 2022Article
- Cell chirality regulates coherent angular motion on small circular substrates.Biophysical journal · 2022Article
- Active chemo-mechanical feedbacks dictate the collective migration of cells on patterned surfaces.Biophysical journal · 2022Article
- Dynamic self-organization of migrating cells under constraints by spatial confinement and epithelial integrity.The European physical journal. E, Soft matter · 2022Article
- Article
- Tracking of Endothelial Cell Migration and Stiffness Measurements Reveal the Role of Cytoskeletal Dynamics.International journal of molecular sciences · 2022Review
- Migrasomes: From Biogenesis, Release, Uptake, Rupture to Homeostasis and Diseases.Oxidative medicine and cellular longevity · 2022Review
- Cell behaviors within a confined adhesive area fabricated using novel micropatterning methods.PloS one · 2022Article
- Learning the dynamics of cell-cell interactions in confined cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cell Migration Guided by Cell-Cell Contacts in Innate Immunity.Trends in cell biology · 2021Review
- Rules of collective migration: from the wildebeest to the neural crest.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Contact inhibition of locomotion (CIL), the repulsive response of cells upon cell-cell contact, has been the predominant paradigm for contact-mediated responses. However, it is difficult for CIL alone to account for the complex behavior of cells within a multicellular environment, where cells often migrate in cohorts such as sheets, clusters, and streams. Although cell-cell adhesion and mechanical interactions play a role, how individual cells coordinate their migration within a multicellular environment remains unclear. Using micropatterned substrates to guide cell migration and manipulate cell-cell contact, we show that contacts between different regions of cells elicit different responses. Repulsive responses were limited to interaction with the head of a migrating cell, while contact with the tail of a neighboring cell promoted migration toward the tail. The latter behavior, termed contact following of locomotion (CFL), required the Wnt signaling pathway. Inhibition of the Wnt pathway disrupted not only CFL but also collective migration of epithelial cells, without affecting the migration of individual cells. In contrast, inhibition of myosin II with blebbistatin disrupted the migration of both individual epithelial cells and collectives. We propose that CFL, in conjunction with CIL, plays a major role in guiding and coordinating cell migration within a multicellular environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.