ArticleProceedings of the National Academy of Sciences of the United States of America2018
HEIP1 regulates crossover formation during meiosis in rice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Crossover control: A key to unlocking genetic diversity in plant breeding.Journal of integrative plant biology · 2026Review
- Disordered protein COSA-2 maintains crossover-specific repair compartments to ensure meiotic crossover maturation.bioRxiv : the preprint server for biology · 2026Article
- The regulatory mechanisms controlling meiotic cross-over patterning in plants.Biochemical Society transactions · 2025Review
- HEIP1 orchestrates pro-crossover protein activity during mammalian meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- RECQ4 restricts non-interfering crossover formation to fine-tune meiotic recombination rates in rice.Plant biotechnology journal · 2025Article
- Meiosis in bulbous flower speciesFrontiers in plant science · 2025Article
- ASYNAPSIS3 has diverse dosage-dependent effects on meiotic crossover formation in Brassica napus.The Plant cell · 2024Article
- Article
- The RING Domain of Rice HEI10 is Essential for Male, But Not Female Fertility.Rice (New York, N.Y.) · 2024Article
- HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- HEIP1 is required for efficient meiotic crossover implementation and is conserved from plants to humans.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Tracing the evolution of the plant meiotic molecular machinery.Plant reproduction · 2023Article
- The meiotic topoisomerase VI B subunit (MTOPVIB) is essential for meiotic DNA double-strand break formation in barley (Hordeum vulgare L.).Plant reproduction · 2023Article
- Why do plants need the ZMM crossover pathway? A snapshot of meiotic recombination from the perspective of interhomolog polymorphism.Plant reproduction · 2023Article
- Crossover interference mechanism: New lessons from plants.Frontiers in cell and developmental biology · 2023Review
- A retrotransposon insertion in MUTL-HOMOLOG 1 affects wild rice seed set and cultivated rice crossover rate.Plant physiology · 2022Article
- Arabidopsis HEAT SHOCK FACTOR BINDING PROTEIN is required to limit meiotic crossovers and HEI10 transcription.The EMBO journal · 2022Article
- FIGNL1 Inhibits Non-homologous Chromosome Association and Crossover Formation.Frontiers in plant science · 2022Article
- Meiosis in crops: from genes to genomes.Journal of experimental botany · 2021Review
- HIGH CROSSOVER RATE1 encodes PROTEIN PHOSPHATASE X1 and restricts meiotic crossovers in Arabidopsis.Nature plants · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During meiosis, the number of double-strand breaks (DSBs) far exceeds the final number of crossovers (COs). Therefore, to identify proteins involved in determining which of these DSBs repaired into COs is critical in understanding the mechanism of CO control. Across species, HEI10-related proteins play important roles in CO formation. Here, through screening for HEI10-interacting proteins via a yeast two-hybrid system, we identify a CO protein HEI10 Interaction Protein 1 (HEIP1) in rice. HEIP1 colocalizes with HEI10 in a dynamic fashion along the meiotic chromosomes and specially localizes onto crossover sites from late pachytene to diplotene. Between these two proteins, HEI10 is required for the loading of HEIP1, but not vice versa. Moreover, mutations of the
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.