Evidence map›Paper›PMID 30275309›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Lesion network localization of free will.

R Ryan Darby, Juho Joutsa, Matthew J Burke, Michael D Fox

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 7 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 7 syntheses or guidelines pooled it, 161 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Article
  10. Review
  11. Robust lesion network mapping reveals genuine symptom-specific networks.bioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Brain network localization of anhedonia.Translational psychiatry · 2026
    Article
  14. Article
  15. Article
  16. Mapping the Neuroanatomy of Dystonia Using Causal Brain Lesions.medRxiv : the preprint server for health sciences · 2025
    Article
  17. Article
  18. Frontal Disorders and Consciousness: A Review.Current neurology and neuroscience reports · 2025
    Review
  19. Article
  20. Alien Hand: Current Research Trends.Current neurology and neuroscience reports · 2025
    Review

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

R Ryan DarbyDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232; darby.ryan@gmail.com foxmdphd@gmail.com.
Juho JoutsaBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical Center, Boston, MA 02215.
Matthew J BurkeBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical Center, Boston, MA 02215.
Michael D FoxBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical Center, Boston, MA 02215; darby.ryan@gmail.com foxmdphd@gmail.com.
Beth Israel Deaconess Medical Center · USAthinoula A. Martinos Center for Biomedical Imaging · USHarvard University · US

Funding

Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9M
Use of Resting-State Networks to Predict the Ideal Site for Brain StimulationK23NS083741 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI FOX, MICHAEL D · 2013 to 2017
$980k
NIMH NIH HHS R01 MH113929NINDS NIH HHS K23 NS083741
6 · The paper itself

Abstract

Our perception of free will is composed of a desire to act (volition) and a sense of responsibility for our actions (agency). Brain damage can disrupt these processes, but which regions are most important for free will perception remains unclear. Here, we study focal brain lesions that disrupt volition, causing akinetic mutism (

Indexed as

Neural PathwaysPersonal AutonomyVolitionBrainBrain DiseasesBrain MappingGyrus CinguliHumansNeuroimagingagencyfree willfunctional connectivitylesionsvolition

Identifiers

PMID30275309
PMCPMC6196503
OpenAlexW2895539805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.