Evidence map›Paper›PMID 30275107›Full record

ArticleThe Journal of cell biology2018

Excitable RhoA dynamics drive pulsed contractions in the early

Jonathan B Michaux, François B Robin, William M McFadden, Edwin M Munro

Abstract read
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed.

  1. Article
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  6. An active matter model captures spatial dynamics of actomyosin oscillations in larval epithelial cells duringProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Learning Epithelial Elasticity via Local Tension Remodeling.bioRxiv : the preprint server for biology · 2025
    Article
  8. Actin network heterogeneity tunes activator-inhibitor dynamics at the cell cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
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  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Patterning of the cell cortex by Rho GTPases.Nature reviews. Molecular cell biology · 2024
    Review
  18. Review
  19. OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jonathan B MichauxDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL.
François B RobinDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL francois.robin@upmc.fr.ORCID 0000-0002-2420-2593
William M McFaddenBiophysics Program, University of Chicago, Chicago, IL.
Edwin M MunroDepartment of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL emunro@uchicago.edu.ORCID 0000-0001-5535-5675

Funding

PREDOCTORAL TRAINING IN GENETICS AND REGULATIONT32GM007197 · NIGMS · UNIVERSITY OF CHICAGO · PI ROTHMAN-DENES, LUCIA B. B · 1985 to 2020
$17.0M
Dynamics and regulation of actomyosin contractility in the C. elegans embryoR01GM098441 · NIGMS · UNIVERSITY OF CHICAGO · PI MUNRO, EDWIN MARSHALL · 2011 to 2020
$2.9M
NIGMS NIH HHS R01 GM098441NIGMS NIH HHS T32 GM007197
6 · The paper itself

Abstract

Pulsed actomyosin contractility underlies diverse modes of tissue morphogenesis, but the underlying mechanisms remain poorly understood. Here, we combined quantitative imaging with genetic perturbations to identify a core mechanism for pulsed contractility in early

Indexed as

ActinsActomyosinAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsEmbryo, NonmammalianGTPase-Activating ProteinsrhoA GTP-Binding ProteinActinsActomyosinCaenorhabditis elegans ProteinsGTPase-Activating ProteinsRGA-3 protein, C elegansRGA-4 protein, C elegansrhoA GTP-Binding Protein

Identifiers

PMID30275107
PMCPMC6279378

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.