Evidence map›Paper›PMID 30275083›Full record

ArticleAntimicrobial agents and chemotherapy2018

Efficacious Analogs of the Lantibiotic Mutacin 1140 against a Systemic Methicillin-Resistant Staphylococcus aureus Infection.

Mengxin Geng, Akshaya Ravichandran, Jerome Escano, Leif Smith

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Selective Bacteriocins: A Promising Treatment forAntibiotics (Basel, Switzerland) · 2023
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. 3 Biotech · 2021
    Article
  10. Review
  11. Review
  12. Review
  13. Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mengxin GengDepartment of Biology, College of Science, Texas A&M University, College Station, Texas, USA.
Akshaya RavichandranDivision of Antimicrobial Discovery, Sano Chemicals Inc., Bryan, Texas, USA.
Jerome EscanoDivision of Antimicrobial Discovery, Sano Chemicals Inc., Bryan, Texas, USA.
Leif SmithDepartment of Biology, College of Science, Texas A&M University, College Station, Texas, USA jsmith@bio.tamu.edu.

Funding

Optimization of the Production and Isolation of the Novel Antifungal OccidiofunginR41AI122441 · NIAID · SANO CHEMICALS, INC · PI SMITH, JAMES LEIF · 2016 to 2017
$530k
Lead Compound Discovery from Engineered Analogs of OccidiofunginR41AI131792 · NIAID · SANO CHEMICALS, INC · PI SMITH, JAMES LEIF · 2017 to 2017
$225k
NIAID NIH HHS R41 AI122441NIAID NIH HHS R41 AI131792
6 · The paper itself

Abstract

Mutacin 1140, a member of the epidermin family of type AI lantibiotics, has a broad spectrum of activity against Gram-positive bacteria. It blocks cell wall synthesis by binding to lipid II. Although it has rapid bactericidal effects and potent activity against Gram-positive pathogens, its rapid clearance and short half-life

Indexed as

AlanineAmino Acid SequenceAmino Acid SubstitutionAnimalsArginineBacteriocinsDrug DesignFemaleKidneyLiverLysineMethicillinMethicillin-Resistant Staphylococcus aureusMiceMice, Inbred BALB CMicrobial Sensitivity TestsAlanineArginineBacteriocinsLysineMethicillinmutacin 1140PeptideslantibioticsMRSAmutacin

Identifiers

PMID30275083
PMCPMC6256755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.